摘要
目的:探讨补气健脾化痰法对2型糖尿病患者中医证候积分与血管内皮功能的影响。方法:将2019年9月-2021年9月北京中医药大学房山医院月华分院收治的148例2型糖尿病患者随机分成对照组和观察组,对照组74例给予二甲双胍+格列美脲治疗,观察组74例给予二甲双胍+格列美脲+补气健脾化痰法治疗,两组均治疗3个月。观察两组的中医证候积分、血糖水平[空腹血糖(Glucose,GLU)、餐后2 h血糖(2 h Postprandial Blood Glucose,2 h PBG)、糖化血红蛋白(Glycosylated Hemoglobin,HbA1c)]、血管内皮功能指标[内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric Oxide,NO)、血管性假血友病因子(von Willebrand Factor,vWF)、血栓调节蛋白(Thrombomodulin,TM)]、临床疗效以及不良反应(恶心、呕吐、头晕、嗜睡)。结果:两组治疗后的口渴喜饮、气短寡言、少食易饥、疲乏无力的评分均降低(P<0.05),且观察组治疗后口渴喜饮、气短寡言、少食易饥、疲乏无力的评分低于对照组(P<0.05);两组治疗后的GLU、2 h PBG、HbA1c均降低(P<0.05),且观察组治疗后的GLU、2 h PBG、HbA1c低于对照组(P<0.05);两组治疗后的ET-1、vWF、TM均降低(P<0.05),NO均升高(P<0.05),且观察组治疗后的ET-1、vWF、TM低于对照组(P<0.05),NO高于对照组(P<0.05);观察组总有效率为95.95%(71/74),高于对照组的81.08%(60/74)(P<0.05);观察组不良反应发生率为9.46%(7/74),与对照组的10.81%(8/74)相近(P>0.05)。结论:补气健脾化痰法对2型糖尿病患者的治疗效果较好,可降低中医证候积分,减轻患者症状,且能改善血糖水平与血管内皮功能指标,总有效率高,不良反应少,有效性与安全性兼备,可推广。
Objective:To explore the effect of the invigorating Qi(气),invigorating spleen and resolving phlegm method on TCM syndrome integral and vascular endothelial function in patients with type 2 diabetes.Methods:A total of 148 patients with type 2 diabetes admitted from September 2019 to September 2021 were randomly divided into the control group and the observation group.Seventy-four patients in the control group were treated with metformin plus glimepiride,and 74 patients in the observation group were treated with metformin,glimepiride plus the invigorating Qi,invigorating spleen and resolving phlegm method,for 3 months.The TCM syndrome score,blood glucose(GLU,2 h PBG,HbA1c)levels,vascular endothelial function indexes(ET-1,NO,vWF,TM),clinical efficacy and adverse reactions(nausea,vomiting,dizziness,lethargy)in the two groups were observed.Results:After treatment,the scores of thirsty,short of breath,silent,hungry,tired and weak in both groups were decreased(P<0.05),and those in the observation group were lower than those in the control group(P<0.05).The GLU,2 h PBG and HbA1c in the two groups after treatment were decreased(P<0.05),and those in the observation group after treatment were lower than the control group(P<0.05).After treatment,ET-1,vWF and TM in both groups were decreased(P<0.05),and NO was increased(P<0.05).ET-1,vWF and TM in the observation group were lower than the control group(P<0.05),and NO was higher than the control group(P<0.05).The total efficiency in the observation group was 95.95%(71/74),which was higher than 81.08%(60/74)in the control group(P<0.05).The incidence of adverse reactions in the observation group was 9.46%(7/74),which was similar to 10.81%(8/74)in the control group(P>0.05).Conclusion:The method of invigorating Qi,invigorating spleen and resolving phlegm has a good therapeutic effect on patients with type 2 diabetes.It can reduce the TCM syndrome score,alleviate the symptoms of patients,and improve the blood glucose level and vascular endothelial function,with good efficacy and fewer adverse reactions.It can be implemented.
出处
《中医临床研究》
2024年第17期133-137,共5页
Clinical Journal Of Chinese Medicine
关键词
补气健脾化痰法
2型糖尿病
中医证候积分
血管内皮功能
不良反应
Method of tonifying Qi,strengthening spleen and resolving phlegm
Type 2 diabetes mellitus
TCM syndrome score
Vascular endothelial function
Adverse reaction
