摘要
目的:探讨本院老年慢病患者药品不良反应(ADR)发生的特点,为保证其用药安全提供参考。方法:调取及筛选出2018年1月—2023年9月本院上报国家ADR监测系统的358例老年慢病患者ADR报告信息,并对ADR涉及的药品剂型、给药途径、种类分布及器官/系统损害等情况进行汇总统计分析。结果:358例老年慢病患者的ADR报告中,最常见的药品剂型是注射液(161例,44.97%);发生ADR主要给药途径为静脉滴注(211例58.94%),其次是口服给药(116例,32.40%);主要涉及抗感染药物(94例,26.26%)、代谢及内分泌系统药物(66例,18.44%)、心血管系统用药(59例,16.48%);主要累及皮肤及其附件系统(97例,27.09%)和消化系统(95例,26.54%);共出现5例(1.40%)严重的ADR,经过抗过敏、升压和氧气支持等治疗后均已好转。结论:老年慢病患者ADR的发生与药品剂型、给药途径、药品种类等因素存在一定的相关性。在临床工作中需提高医护人员对ADR的鉴别及处置能力,加强老年患者用药监测,降低ADR发生率,保证其用药安全。
Objective:To explore the characteristics of adverse drug reactions(ADR)in elderly patients with chronic diseases at our hospital and provide a reference for ensuring the safety of drug use.Methods:The ADR report information of358 elderly patients with chronic diseases reported to the national ADR monitoring system in our hospital from January 2018 to September 2023 was retrieved and screened,and the drug dosage forms,route of administration,species distribution,and organ/system damage involved in ADR were summarized and statistically analyzed.Results:In the ADR reports of 358 elderly patients with chronic diseases,the most common drug dosage form was injection(161 cases,44.97%);The main administration route of ADR was intravenous infusion(211 cases 58.94%),followed by oral administration(116 cases,32.40%).Anti-infectious drugs(94 cases,26.26%),metabolic and endocrine system drugs(66 cases,18.44%),and cardiovascular system drugs(59 cases,16.48%)were mainly involved.It mainly involved the skin and accessory system(97 cases,27.09%)and the digestive system(95 cases,26.54%).A total of five cases(1.40%)of severe ADR occurred,and all of them improved after anti-allergic,vasopressor,and oxygen support treatments.Conclusions:The occurrence of ADR in elderly patients with chronic diseases is related to drug dosage form,routeof administration,drugtype,and other factors.In clinical practice,it is necessary to improve the ability of medical staff to identify and handle ADR,strengthen drug monitoring in elderly patients,reduce the incidence of ADR,and ensure the safety of drug use.
作者
刘蕊
Liu Rui(Tianjin Wuqing District People's Hospital,Tianjin 301700)
出处
《天津药学》
2024年第3期16-20,共5页
Tianjin Pharmacy
基金
天津市武清区科技局(No.WQKJ202128)。
关键词
老年慢病患者
药品不良反应
统计分析
合理用药
医疗机构
elderly patients with chronic diseases
adverse drug reaction
statistical analysis
rational use
medical institution
