摘要
2-{[4-(溴甲基)-2,6-二氯苯基]氨基}苯甲酸乙酯(化合物1)与氰化钾发生氰化反应得到甲氯芬那酸衍生物——2-{[2,6-二氯-4-(氰甲基)苯基]氨基}苯甲酸乙酯(化合物2)。考察了物料比、反应溶剂和反应温度对化合物2的影响,并采用XRD单晶衍射对化合物2进行了表征。结果发现,当物料比为n(氰化钾)∶n(化合物1)=2.0∶1,乙腈为反应溶剂,在60℃反应4h的条件下,产物化合物2的收率达到77.1%(以化合物1计)。
The target compound ethyl 2-((2,6-dichloro-4-(cyanomethyl)phenyl)amino)benzoate(compound 2) was synthesized by cyanide reaction of ethyl 2-((4-(bromomethyl)-2,6-dichlorophenyl)amino)benzoate(compound 1) with potassium cyanide.The effects of material ratio, reaction solvent and reaction temperature on compound 2 were investigated, and the compound 2 was characterized by XRD single crystal diffraction.The results showed that the yield was 77.1%(calculated as compound 1) when the ratio of n(potassium cyanide)∶n(compound 1) was 2.0∶1,acetonitrile was used as the reaction solvent and the reaction time was 4h at 60℃.
作者
赵梅梅
杜漠
王一寓
唐文强
ZHAO Mei-mei;DU Mo;WANG Yi-yu;TANG Wen-qiang(Higher Vocational College,Shaanxi Institute of International Trade&Commerce,Xianyang 712046,China;Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis,Xianyang 712046,China)
出处
《精细与专用化学品》
CAS
2024年第7期45-47,55,共4页
Fine and Specialty Chemicals
基金
陕西国际商贸学院“中药药效物质研究”创新团队资助项目(SSY18TD02)。
关键词
甲氯芬那酸衍生物
氰化反应
条件优化
单晶衍射
meclofenamic acid derivatives
cyanide reaction
condition optimization
single crystal diffraction
