摘要
目的分析中医药联合音乐疗法对老年晚期肠道肿瘤的临床疗效及其机制。方法选取2021年1月—2022年3月南通市中医院老年科收治的90例老年晚期肠道肿瘤患者为研究对象,随机分为治疗组A(中药汤剂口服+音乐疗法+姑息治疗)、治疗组B(中药汤剂口服+姑息治疗)、对照组(姑息治疗)各30例,对比3组疗效、治疗前后负性情绪[焦虑自评量表(SAS)、抑郁自评量表(SDS)]、炎症反应[中性粒细胞与淋巴细胞比值(NLR)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30 V3.0中文版)、匹茨堡睡眠质量指数(PSQI)、不良反应。结果治疗组A总有效率90.00%高于对照组66.66%(P<0.05),治疗组A总有效率高于治疗组B 76.67%,但差异无统计学意义(P>0.05);治疗后治疗组A的SAS评分、SDS评分低于治疗组B和对照组(P<0.05);治疗后治疗组A的NLR、TNF-α、IL-6均低于治疗组B和对照组(P<0.05);治疗后治疗组A的EORTC QLQ-C30评分、PSQI评分低于治疗组B和对照组(P<0.05);3组的不良反应情况比较差异无统计学意义(P>0.05)。结论中医药联合音乐疗法对老年晚期肠道肿瘤患者有较好临床疗效,其机制可能与下调炎症因子有关,利于减轻焦虑抑郁情绪,提高生命质量及睡眠。
Objective To analyze the clinical efficacy and mechanism of traditional Chinese medicine combined with music therapy in elderly patients with advanced intestinal tumors.Methods Ninety elderly patients with advanced intestinal tumors who were admitted to the department of geriatrics,Nantong hospital of traditional Chinese medicine from January 2021 to March 2022 were selected as the study subjects.They were randomly divided into the treatment group A(oral traditional Chinese medicine decoction combined with music therapy and palliative treatment),the treatment group B(oral traditional Chinese medicine decoction combined with palliative treatment)and the control group(palliative treatment),with 30 patients in each group.Efficacy,negative emotions[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)],inflammatory reactions[neutrophil to lymphocyte ratio(NLR),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)],the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30),Pittsburgh sleep quality index(PSQI)and adverse reactions were compared among the 3 groups.Results The total effective rate in the treatment group A(90.00%)was higher than that in the control group(66.66%)(P<0.05).The total effective rate in the treatment group A was slightly higher than that in the treatment group B(76.67%)(P>0.05).After treatment,the SAS scores,SDS scores,NLR,TNF-α,IL-6,the EORTC QLQ-C30 scores and PSQI scores in the treatment group A were lower than those in the treatment group B and the control group(all P<0.05).Adverse reactions in the 3 groups were similar(P>0.05).Conclusion Traditional Chinese medicine combined with music therapy can achieve good clinical effects in elderly patients with advanced intestinal tumors.The mechanism may be down regulation of inflammatory factors.In addition,the treatment can alleviate anxiety and depression,and improve the quality of life and sleep.
作者
范春来
蔡青青
季晓杭
邢科
徐广飞
FAN Chunai;CAI Qingqing;JI Xiaohang;XING Ke;XU Guangfei(Nantong Hospital of Traditional Chinese Medicine,Nantong 226001,Jiangsu,China)
出处
《辽宁中医药大学学报》
CAS
2024年第8期217-220,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
南通市科技计划项目(JCZ20193)。
关键词
中医药
音乐疗法
老年
肠道肿瘤
临床疗效
机制
traditional Chinese medicine
music therapy
elderly
testinal tumor
clinical efficacy
mechanism
