摘要
目的探讨在孕早期用C反应蛋白(CRP)、半乳糖凝集素-13(Gal-13)和糖化血红蛋白(HbA1c)预测妊娠期糖尿病的临床价值。方法回顾性分析2017年5月至2023年5月于西华县妇幼保健院门诊建档并产检的98例孕妇的临床资料,根据是否合并妊娠期糖尿病将其分为两组,观察组(48例)合并妊娠期糖尿病,对照组(50例)未合并妊娠期糖尿病,比较两组孕妇血清CRP、Gal-13、HbA1c水平,分析影响妊娠期糖尿病发生的危险因素,探究血清CRP、Gal-13、HbA1c对妊娠期糖尿病的预测价值。结果观察组BMI、CRP、HbA1c水平均高于对照组,Gal-13低于对照组,差异有统计学意义(P<0.05);CRP、HbA1c水平较高、Gal-13表达水平较低均为影响妊娠期糖尿病发病的因素(P<0.05);血清CRP、Gal-13、HbA1c联合检测妊娠期糖尿病受试者工作曲线下面积(AUC)值高于单项检测(Z=2.547、3.676、2.101,P<0.05)。结论血清CRP、Gal-13、HbA1c均为妊娠期糖尿病发病影响因素,均可作为妊娠期糖尿病的预测指标。
Objective To explore the clinical value of C-reactive protein(CRP),Galectin-13(Gal-13),and Glycated hemoglobin A1c(HbA1c)in predicting gestational diabetes mellitus in early pregnancy.Methods The clinical data of 98 pregnant women who were registered and underwent prenatal examination in the outpatient clinic of Xihua County Maternal and Child Health Hospital from May 2017 to May 2023 were retrospectively analyzed.According to whether they had gestational diabetes mellitus,they were divided into two groups:the observation group(48 cases)with gestational diabetes mellitus and the control group(50 cases)without gestational diabetes mellitus.The levels of serum CRP,Gal-13,and HbA1c in the two groups of pregnant women were compared,the risk factors affecting the occurrence of gestational diabetes mellitus were analyzed,and the predictive value of serum CRP,Gal-13,and HbA1c for gestational diabetes mellitus was explored.Results The BMI,CRP,and HbA1c levels of the observation group were higher than those of the control group,and Gal-13 was lower than that of the control group,and the difference was statistically significant(P<0.05).Higher levels of CRP and HbA1c and lower expression levels of Gal-13 were all factors affecting the occurrence of gestational diabetes mellitus(P<0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve for the combined detection of serum CRP,Gal-13,and HbA1c for gestational diabetes mellitus was higher than that of single detection(Z=2.547,3.676,2.101,P<0.05).Conclusion Serum CRP,Gal-13,and HbA1c are all factors affecting the occurrence of gestational diabetes mellitus,and they can all be used as predictive indicators for gestational diabetes mellitus.
作者
张淑丽
石云英
李威锋
ZHANG Shuli;SHI Yunying;LI Weifeng(Department of Obstetrics and Gynecology,Xihua County Maternal and Child Health Hospital,Zhoukou Henan 466600,China)
出处
《临床研究》
2024年第8期54-57,共4页
Clinical Research
