摘要
探讨保肾排石膏联合间苯三酚对行体外冲击波碎石(ESWL)术后输尿管结石患者的排石、镇痛效果及炎症因子的影响。选取2020年10月—2022年8月石家庄市中医院泌尿外科收治的输尿管结石患者128例,据治疗方法不同均分为观察组和对照组。对照组术后当日予间苯三酚静脉滴注,每日1次,连用7 d;观察组则在对照组基础上于术后当日予保肾排石膏口服,每日2次,连用7 d。比较两组排石效率、排石及住院时间,术后疼痛缓解及不良反应情况以及炎症因子水平的变化。观察组治疗后总有效率为90.62%,高于对照组的76.56%(P<0.05);观察组结石排出时间及住院时间均短于对照组(P<0.01);两组术后7 d视觉模拟评分量表(VAS)评分均低于术后3 d,且观察组术后3、7 d VAS评分均低于对照组(P<0.01);两组总不良反应发生率比较,差异无统计学意义(χ^(2)=1.736,P=0.188);观察组肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)以及白细胞介素-6(IL-6)水平相比于对照组有所下降。保肾排石膏联合间苯三酚用于ESWL术后输尿管结石患者,可明显提高排石率、缩短排石及住院时间,并可有效缓解疼痛,且安全性好,降低炎症反应,值得临床推广应用。
To investigate the effect of baoshen paishi cream combined with phloroglucinol on stone removal and analgesia in patients with ureteral calculi after extracorporeal shock wave lithotripsy(ESWL),128 patients with ureteral calculi treated in the Department of Urology of Shijiazhuang Hospital of Traditional Chinese Medicine from October 2020 to August 2022 were selected.According to different treatment methods,they were equally divided into observation group and control group.The control group was given phloroglucinol intravenous drip on the day after operation,once a day for 7 days.On the basis of the control group,the observation group was given baoshen paishi cream on the day after operation,twice a day,used together for 7 d.The stone removal efficiency,stone removal and hospital stay,postoperative pain relief,adverse reactions and inflammatory factor level were compared between the two groups.The total effective rate in observation group was 90.62%,which was higher than 76.56%in control group(P<0.05).The stone excretion time and hospital stay in observation group were shorter than those in control group(P<0.01).The scores of visual analogue scale(VAS)at 7 days after operation in two groups were lower than those at 3 days after operation,and the VAS scores at 3 and 7 days after operation in observation group were lower than those in control group(P<0.01).There was no significant difference in the incidence of total adverse reactions between two groups(χ^(2)=1.736,P=0.188).Tumor necrosis factor(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)were decreased compared with the control group.Baoshen paishi cream combined with phloroglucinol in patients with ureteral calculi after ESWL can significantly improve the stone removal rate,shorten the stone removal and hospital stay time,and effectively relieve pain,with good safety and reduce inflammatory reaction,which is worthy of popularization and application.
作者
苑士利
刘永存
侯书恒
YUAN Shili;LIU Yongcun;HOU Shuheng(Department of Anoenterology,Hospital of Traditional Chinese Medicine in Shijiazhuang,Shijiazhuang 050051,China;Department of Surgery,Hospital of Traditional Chinese Medicine in Shijiazhuang,Shijiazhuang 050051,China;Department of Emergency,Hospital of Traditional Chinese Medicine in Shijiazhuang,Shijiazhuang 050051,China)
出处
《药物生物技术》
CAS
2024年第3期286-290,共5页
Pharmaceutical Biotechnology
基金
河北省中医药管理局科研计划项目(No.2021249)。
关键词
输尿管结石
保肾排石膏
间苯三酚
体外冲击波碎石术
排石率
炎症因子
视觉模拟评分量表
药物毒性
ureteral calculi
baoshen paishi cream
phloroglucinol
extracorporeal shock wave lithotripsy
stone discharge rate
inflammatory factors
visual analogue scale
drug toxicity
