摘要
目的:探讨超声下聚桂醇化学消融联合米非司酮治疗子宫肌瘤的临床价值。方法:选择2022年4月—2023年4月射阳县人民医院接收的80例子宫肌瘤患者作为研究对象,通过随机数表法分为对照组与观察组,各40例。对照组予以米非司酮治疗,观察组予以超声下聚桂醇化学消融联合米非司酮治疗。比较两组临床疗效及治疗前后肌瘤体积、肌瘤直径、卵巢功能[雌二醇(E_(2))、促卵泡激素(FSH)、黄体生成激素(LH)]。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肌瘤体积、肌瘤直径、卵巢功能比较,差异无统计学意义(P>0.05);治疗后,观察组肌瘤体积小于对照组,肌瘤直径短于对照组,E_(2)、FSH、LH水平低于对照组,差异有统计学意义(P<0.05)。结论:相比单独使用米非司酮治疗,超声下聚桂醇化学消融联合米非司酮治疗子宫肌瘤在提高治疗有效率、减小肌瘤体积、缩短肌瘤直径及改善卵巢功能方面效果更显著。
Objective:To investigate the clinical value of ultrasound-guided Polidocanol chemical ablation combined with Mifepristone in the treatment of uterine fibroids.Method:A total of 80 patients with uterine fibroids who admitted to Sheyang County People's Hospital from April 2022 to April 2023 were selected as the study objects and divided into the control group and the observation group by random number table method,with 40 cases in each group.The control group was treated with Mifepristone,and the observation group was treated with ultrasound-guided Polidocanol chemical ablation combined with Mifepristone.The clinical efficacy,fibroids volume,fibroids diameter and ovarian function[estradiol(E_(2)),follicle-stimulating hormone(FSH),luteinizing hormone(LH)]before and after treatment were compared between two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the fibroids volume,fibroids diameter and ovarian function between two groups(P>0.05);after treatment,the fibroids volume in the observation group was smaller than that in the control group,the fibroids diameter was shorter than that in the control group,and the levels of E_(2),FSH and LH were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Compared with Mifepristone alone,ultrasound-guided Polidocanol chemical ablation combined with Mifepristone in the treatment of uterine fibroids is more effective in improving the treatment efficiency,reducing the fibroids volume,shortening the fibroids diameter and improving ovarian function.
作者
高晶晶
徐俊
陈立萍
GAO Jingjing;XU Jun;CHEN Liping(Sheyang County People's Hospital,Sheyang 224300,China;不详)
出处
《中外医学研究》
2024年第19期108-111,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
江苏医药职业学院校地协同创新研究项目(20239318)。
关键词
超声下聚桂醇化学消融
米非司酮
子宫肌瘤
临床疗效
卵巢功能
Ultrasound-guided Polidocanol chemical ablation
Mifepristone
Uterine fibroids
Clinical efficacy
Ovarian function
