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DCE-MRI,DWI联合血清肿瘤标志物对乳腺良恶性肿瘤的鉴别诊断价值

Differential Diagnostic Value of DCE-MRI,DWI Combined with Serum Tumor Markers for Benign and Malignant Breast Tumors
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摘要 目的探讨DCE-MRI,DWI联合血清肿瘤标志物对乳腺良恶性肿瘤的鉴别诊断价值。方法选取乳腺结节患者106例,均为单发结节,分析应用DCE-MRI,DWI联合血清肿瘤标志物对乳腺肿瘤良恶性的鉴别诊断价值。结果乳腺良恶性结节DWI参数比较发现,恶性结节ADC值显著高于对照组(P<0.05);乳腺良恶性结节DCE-MRI参数比较发现,恶性结节中不规则形态、不均匀强化及TIC为Ⅲ型的占比均高于良性结节(P<0.05);乳腺恶性结节组的CA153及CEA的水平显著高于乳腺良性结节组(P<0.05)。ROC曲线结果显示,DCE-MRI、DWI、CA153、CEA单独及联合应用的AUC分别为0.745、0.732,0.653、0.593及0.852。结论DCE-MRI、DWI联合血清肿瘤标志物对乳腺肿瘤良恶性的鉴别诊断力较高,具有较好的临床应用价值。 Objective To investigate the differential diagnostic value of DCE-MRI,DWI combined with serum tumor markers for benign and malignant breast tumors.Methods 106 cases of breast nodules were selected,all of which were single nodules,and analyzed the differential diagnostic value of applying DCE-MRI,DWI combined with serum tumor markers on the benign and malignant breast tumors.Results Comparison of DWI parameters of benign and malignant breast nodes revealed that the ADC values of malignant nodes were significantly higher than those of the control group(P<0.05);Comparison of DCE-MRI parameters of benign and malignant breast nodes revealed that the proportion of malignant nodes with irregular morphology,inhomogeneous enhancement and TIC of typeⅢwere higher(P<0.05);The levels of CA153 and CEA were significantly higher in the group of malignant breast nodes than in the group of benign breast The levels of CA153 and CEA were significantly higher in the group with malignant nodules than in the group with benign nodules(P<0.05);The results of ROC curves showed that the AUCs of DCE-MRI,DWI,CA15,CEA single and combined application were 0.745,0.732,0.653,0.593 and 0.852,respectively.Conclusion DCE-MRI and DWI combined with serum tumor markers have high differential diagnostic power for benign and malignant breast tumors,and have good clinical application value.
作者 王良敏 魏红霞 龚雪 WANG Liangmin;WEI Hongxia;GONG Xue(The Second People's Hospital of Nanyang,Nanyang,473000)
出处 《实用癌症杂志》 2024年第8期1350-1352,共3页 The Practical Journal of Cancer
关键词 动态增强磁共振成像 MRI扩散加权成像 乳腺肿瘤良恶性 鉴别诊断价值 DCE-MRI MRI DWI Breast tumor benign and malignant Differential diagnostic value
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