摘要
脑胶质瘤作为全球病死率最高的恶性肿瘤之一,其发病机制尚不明确。尽管手术、放疗、化疗、免疫治疗和电场治疗等在治疗脑胶质瘤方面取得了较好的临床疗效,但这些治疗方法存在不良反应大、患者经济和心理负担重等问题。近年来,中医凭借多成分、多靶点、多途径的特点在肿瘤治疗中成为亮点,且其不良反应小,可与西医在治疗上优势互补。多项研究表明,中药单体活性成分和中药复方可通过重塑肿瘤微环境(TME),抑制脑胶质瘤细胞的增殖、侵袭、迁移、血管新生,促进脑胶质瘤细胞的凋亡、自噬,从而延缓脑胶质瘤发展进程,达到治疗脑胶质瘤的作用。近几年与此相关的研究成果颇多,现存的总结文献纳入不完全,缺乏系统的整理,故而该文从TME与脑胶质瘤相关性出发,旨在系统总结中医药干预TME治疗脑胶质瘤的相关作用机制,以期为脑胶质瘤的治疗提供新的靶点、新的视角和新的思路,促进中医药现代化发展。
Brain glioma is one of the malignant tumors with the highest mortality rate in the world,but its pathogenesis is not yet clear.Although surgery,radiotherapy,chemotherapy,immunotherapy,and electric field therapy have achieved good clinical efficacy in treating brain gliomas,these treatment methods have problems such as high adverse reactions,as well as heavy economic and psychological burdens on patients.In recent years,traditional Chinese medicine(TCM)has become a highlight in tumor treatment due to its multi-component,multi-target,and multi-pathway characteristics.Its low adverse reactions can complement the advantages of Western medicine in treatment.Multiple studies have shown that active ingredients of TCM monomers and compound formulas can reshape the tumor microenvironment(TME),inhibit the proliferation,invasion,migration,and angiogenesis of brain glioma cells,and promote apoptosis and autophagy of brain glioma cells,thereby delaying the process of brain glioma development and achieving therapeutic effects on brain glioma.In recent years,there have been many research achievements related to this topic,and the existing summary literature is not fully included and lacks systematic organization.Therefore,this study investigated the correlation between TME and brain glioma,aiming to systematically summarize the relevant mechanisms of TCM intervention in the treatment of brain glioma,provide new targets,perspectives,and ideas for the treatment of brain glioma,and promote the modernization of TCM.
作者
齐帆
赵晓平
范小璇
孟凯强
吕晶
黄岚
侯玉
冯照群
QI Fan;ZHAO Xiaoping;FAN Xiaoxuan;MENG Kaiqiang;LYU Jing;HUANG Lan;HOU Yu;FENG Zhaoqun(The First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China;Ksunsan National University,Gunsan 54150,South Korea)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第16期303-314,共12页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81873288)
陕西省中西医结合临床协作创新项目(2020-ZXY-007)
陕西省中医脑病临床医学研究中心建设项目(陕科社发[2017]176号)
陕西中医药大学研究生质量提升工程专项(XSJL202317)
国家中医药管理局高水平中医药重点学科建设项目(国中医药人教函[2023]85号)。
关键词
肿瘤微环境
脑胶质瘤
中医药
分子机制
研究进展
tumor microenvironment
brain glioma
traditional Chinese medicine
molecular mechanisms
research progress
