摘要
目的探究血清肿瘤标志物联合检测在乳腺癌早期中的诊断效能。方法目的选取2022年8月—2023年8月江苏大学附属武进医院收治的187例疑似乳腺癌患者作为研究对象,所有患者接受血清标志物糖类抗原153(Carcinoembryonic Antigen 153,CA153)、糖类抗原125(Cancer Antigen 125,CA125)、癌胚抗原(Car-cinoembryonic Antigen,CEA)联合检测,以病理学检查作为金标准,结合受试者工作特征(Receiver Operating Characteristic,ROC)曲线分析血清标志物联合检测诊断效能,通过Kappa值进行一致性分析。结果经金标准诊断,187例疑似乳腺癌患者中,155例确诊为乳腺癌,32例为良性乳腺疾病;血清标志物联合检测结果显示,154例为乳腺癌,33例为良性乳腺疾病。血清标志物联合检测的AUC为0.921,灵敏度96.77%,特异度87.50%。一致性分析结果显示,Kappa值为0.832。结论血清肿瘤标志物联合检测在保证安全、无创的同时,具有较高的诊断效能。
Objective To explore the diagnostic efficacy of combined detection of serum tumor markers in the early stage of breast cancer.Methods A total of 187 suspected breast cancer patients admitted to Wujin Hospital Affiliated to Jiangsu University from August 2022 to August 2023 were purposefully selected as the study objects.All patients received serum markers of carcinoembryonic antigen 153(CA153),cancer antigen 125(CA125),and carcinoembry-onic antigen(CEA)combined detection.Pathological examination was used as the gold standard,the diagnostic effi-cacy of serum markers combined with receiver operating characteristic(ROC)curve was analyzed,and the consistency analysis was performed by Kappa value.Results Among 187 suspected breast cancer patients diagnosed by gold stan-dard,155 cases were confirmed as breast cancer and 32 cases were benign breast disease.Combined detection of se-rum markers showed 154 cases of breast cancer and 33 cases of benign breast disease.The AUC of serum markers combined detection was 0.921,the sensitivity was 96.77%,and the specificity was 87.50%.Consistency analysis showed that Kappa value was 0.832.Conclusion Combined detection of serum tumor markers not only ensures safety and non-invasive,but also has high diagnostic efficacy.
作者
吴洁
李文艳
徐馨培
WU Jie;LI Wenyan;XU Xinpei(Department of Laboratory,Wujin Hospital Affiliated to Jiangsu University,Changzhou 213000,Jiangsu,China)
出处
《系统医学》
2024年第12期168-170,174,共4页
Systems Medicine
关键词
血清肿瘤标志物
联合检测
乳腺癌早期
诊断效能
糖类抗原153
糖类抗原125
癌胚抗原
Serum tumor markers
Joint detection
Early breast cancer
Diagnostic effectiveness
Carbohydrate antigen 153
Carbohydrate antigen 125
Carcinoembryonic antigen
