摘要
目的:分析甲巯咪唑联合丙硫氧嘧啶治疗甲状腺功能亢进症的临床效果。方法:选取2022年1—12月泰安市东平县人民医院收治的90例甲状腺功能亢进症患者作为研究对象,随机分为研究组和参照组,各45例。参照组给予丙硫氧嘧啶片治疗,研究组在参照组基础上给予甲巯咪唑软膏治疗。比较两组治疗效果。结果:治疗后,两组游离三碘甲状腺原氨酸、游离甲状腺素、三碘甲状腺原氨酸、四碘甲状腺原氨酸水平低于治疗前,且研究组低于参照组,差异有统计学意义(P<0.001)。治疗后,两组丙氨酸氨基转移酶、γ-谷氨酰转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶水平低于治疗前,且研究组低于参照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于参照组,差异有统计学意义(P=0.049)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:甲巯咪唑联合丙硫氧嘧啶治疗甲状腺功能亢进症的临床效果显著,可改善甲状腺功能、肝功能,降低不良反应发生率。
Objective:To analyze the clinical effect of thiamazole combined with propylthiouracil in treatment of hyperthyroidism.Methods:A total of 90 hyperthyroidism patients admitted to Dongping County People's Hospital in Taian City from January 2022 to December 2022 were selected as the study subjects.They were randomly divided into study group and reference group,with 45 cases in each group.The reference group was treated with propylthiouracil and the study group was treated with thia mazolecrea montheba⁃sis of the reference group.The treatmenteffectofthe two group swascompared.Results:Aftertreatment,the levelsoffree triiodothyro⁃nine,free thyroxine,triiodothyronine and tetraiodothyronine in the two groupswere lowerthan those before treatment,and the levelsin the study group were lower than those in the reference group,with a statistically significant difference(P<0.001).After treatment,the levels of alanine aminotransferase,γ-glutamyl transferase,aspartate aminotran sferase and alkaline phosphatase in the two groups were lower than those before treatment,and the levels in the study group were lower than those in the reference group,with a statisti⁃cally significant difference(P<0.05).The total effectiverate of treatmentin the studygroup was higher than that in the reference group,and the difference was statistically significant(P=0.049).The rewas no significantdifferencein the to talincidence of adversereactions between the two groups(P>0.05).Conclusion:Thiamazole combined with propylthiouracil has significant effects in treatment of hy⁃perthyroidism,and can improve thyroid function and liver function,and reduce the incidence of adverse reactions.
作者
冯清
Feng Qing(Department of Endocrinology,Dongping County People's Hospital,Taian 271500,Shandong Province,China)
出处
《中国社区医师》
2024年第18期11-13,共3页
Chinese Community Doctors
