摘要
目的 比较当归芍药散与布洛芬口崩片治疗原发性痛经气滞血瘀证的临床疗效。方法 前瞻性选取2020年1月—2023年12月琼海市中医院收治的原发性痛经气滞血瘀证患者144例作为研究对象,采用随机数字表法分为西药治疗组和中药治疗组,各72例。西药治疗组患者接受布洛芬口崩片治疗,中药治疗组患者接受当归芍药散治疗。2组患者均连续治疗3个月经周期。比较2组临床疗效,治疗前后痛经程度评分、血清学指标[前列腺素F_(2)α(PGF_(2)α)、前列腺素E_(2)(PGE_(2))]。结果 中药治疗组患者治疗总有效率为93.06%,高于西药治疗组的77.78%(χ^(2)=6.746,P=0.009)。治疗3个月经周期后,2组患者痛经程度评分低于治疗前,且中药治疗组低于西药治疗组(P<0.01);2组患者血清PGF_(2)α水平低于治疗前,血清PGE_(2)水平高于治疗前,且中药治疗组低/高于西药治疗组(P<0.05或P<0.01)。结论 采用布洛芬口崩片及当归芍药散治疗原发性痛经气滞血瘀证均能通过降低PGF_(2)α、提高PGE_(2)水平而减轻痛经程度,但当归芍药散的效果更佳。
Objective This study aimed to compare the curative effect of the Danggui Shaoyao powder and ibuprofen orally disintegrating tablets in the treatment of primary dysmenorrhea with Qi stagnation and blood stasis syndrome.MethodsA total of 144 cases of primary dysmenorrhea patients with Qi stagnation and blood stasis syndrome were recruited from January 2020 to December 2023 in Qionghai Hospital of Traditional Chinese Medicine as research objects,all patients were grouped into the western medicine group and the TCM group,72 cases in each group.Patients in the western medicine group were given ibuprofen orally disintegrating tablets,patients in the TCM group were given Danggui Shaoyao powder,all patients were given 3 menstrual cycles.Clinical effect,dysmenorrhea severity score,serum markers(PGF_(2)α,PGE_(2)) before and after treatment were examined and compared between the two groups.Results Total effective rate of the TCM group was 93.06%,which was higher than 77.78% of the western medicine group(χ^(2)=6.746,P=0.009).After 3 menstrual cycles of treatment,dysmenorrhea severity score of the two groups was lower than that before treatment,and the TCM group was lower than that in the western medicine group(P<0.01);Serum PGF_(2)α level in the two groups was lower than that before treatment,serum PGE_(2) level was higher than that before treatment,and the serum levels of PGF_(2)α and PGE_(2) in the TCM group were lower/higher than those in the western medicine group(P<0.05 or P<0.01).Conclusion This study indicates that the Danggui Shaoyao power and ibuprofen orally disintegrating tablets all can effectively ameliorate dysmenorrhea symptom by decreasing PGF_(2)α and increasing PGE_(2) levels in the treatment of primary dysmenorrhea patients with Qi stagnation and blood stasis syndrome.Of the two,Danggui Shaoyao power has a better clinical outcome.
作者
刘穗
岳昌华
罗小妹
王玲敏
刘洋洋
牛向馨
LIU Sui;YUE Changhua;LUO Xiaomei;WANG Lingmin;LIU Yangyang;NIU Xiangxin(Department of Gynecology,Qionghai Hospital of Traditional Chinese Medicine,Hainan Province,Qionghai 571400,China)
出处
《临床合理用药杂志》
2024年第21期39-42,共4页
Chinese Journal of Clinical Rational Drug Use
基金
海南省自然科学基金高层次人才项目(820RC789)。
关键词
原发性痛经
气滞血瘀证
当归芍药散
布洛芬口崩片
疗效比较
Primary dysmenorrhea
Qi stagnation and blood stasis syndrome
Danggui Shaoyao powder
Ibuprofen orally disintegrating tablets
Comparative effect
