摘要
目的分析含呋喃唑酮四联疗法治疗耐药幽门螺杆菌(Hp)感染老年患者的临床效果。方法选择100例耐药幽门螺杆菌感染老年患者为研究样本,现结合受试者干预方式差异分为新式组(50例)、传统组(50例)。传统组使用阿莫西林+奥美拉唑+克拉霉素+胶体果胶铋方案治疗,新式组使用胶体果胶铋+阿莫西林+奥美拉唑+呋喃唑酮方案治疗。对比两组治疗总有效率,幽门螺杆菌清除时间,干预前后血浆胃动素、胃泌素水平,不良反应发生率。结果传统组治疗总有效率为82.00%,新式组为96.00%,相较于传统组,新式组治疗总有效率更高,组间数据存在统计学意义(P<0.05)。传统组幽门螺杆菌根除时间为(6.39±1.57)d,新式组幽门螺杆菌根除时间为(5.25±1.52)d,和传统组相比,新式组幽门螺杆菌清除时间明显更短,组间数据存在统计学意义(P<0.05)。干预后,新式组胃泌素为(73.25±3.92)pg/ml、血浆胃动素为(432.25±41.25)pg/ml,传统组分别为(88.36±4.28)、(345.26±40.27)pg/ml,相较于传统组,新式组的血浆胃动素、胃泌素水平改善情况更好,组间数据存在统计学意义(P<0.05)。传统组不良反应发生率为12.00%,新式组为10.00%,两组不良反应发生率无明显差别(P>0.05)。结论含呋喃唑酮四联疗法治疗耐药幽门螺杆菌感染老年患者能取得满意成效,值得进一步推广以及应用。
Objective To analyze the clinical effect of furazolidone-containing quadruple therapy in the treatment of drug-resistant Helicobacter pylori(Hp)infection in elderly patients.Methods 100 elderly patients with drug-resistant Helicobacter pylori infection were selected as study samples.Based on the differences in intervention methods of the subjects,patients were divided into a new group(50 cases)and a traditional group(50 cases).The traditional group was treated with amoxicillin+omeprazole+clarithromycin+colloidal bismuth pectin regimen,and the new group was treated with colloidal bismuth pectin+amoxicillin+omeprazole+furazolidone regimen.The total effective rate,clearance time of Helicobacter pylori,plasma levels of motilin and gastrin before and after intervention and the incidence of adverse reactions were compared between the two groups.Results The total effective rate was 82.00%in the traditional group and 96.00%in the new group.Compared with the traditional group,the total effective rate in the new group was higher,and the inter-group data had statistical significance(P<0.05).The clearance time of Helicobacter pylori in the traditional group was(6.39±1.57)d,and that in the new group was(5.25±1.52)d.Compared with the traditional group,the clearance time of Helicobacter pylori in the new group was significantly shorter,and the inter-group data had statistical significance(P<0.05).After intervention,the serum levels of gastrin and motilin in the new group were(73.25±3.92)pg/ml and(432.25±41.25)pg/ml,and those in the traditional group were(88.36±4.28)and(345.26±40.27)pg/ml.Compared with the traditional group,the plasma levels of motilin and gastrin in the new group were better,and the inter-group data had statistical significance(P<0.05).The incidence of adverse reactions was 12.00%in the traditional group and 10.00%in the new group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Furazolidone-containing quadruple therapy can achieve satisfactory results in the treatment of drug-resistant Helicobacter pylori infection in elderly patients.This scheme is worthy of further promotion and application.
作者
成金弟
CHENG Jin-di(Department of gastroenterology,Guannan County People's Hospital,Lianyungang 222500)
出处
《中国现代药物应用》
2024年第14期115-118,共4页
Chinese Journal of Modern Drug Application
关键词
耐药
幽门螺杆菌
感染
老年
呋喃唑酮
Drug-resistant
Helicobacter pylori
Infection
Old age
Furazolidone
