摘要
目前有关肠道菌群与类风湿关节炎、系统性红斑狼疮等自身免疫性疾病的相关性已得到证实,肠道菌群与阿尔茨海默病、帕金森病等神经系统退行性病变的相关性研究也逐步深入。然而,肠道菌群与神经系统自身免疫性疾病的相关性研究仍处于起步阶段,其影响神经系统自身免疫性疾病的机制尚未完全阐明。该文通过查阅近年来关于肠道菌群与神经系统自身免疫性疾病的文献,阐述了肠道菌群与神经系统自身免疫性疾病的相互作用,以及通过靶向肠道菌群的方法辅助治疗神经系统自身免疫性疾病的研究现状。
At present,studies have confirmed the association of gut microbiota with the autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus,and in⁃depth studies are being conducted to investigate the association between gut microbiota and the neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.However,the research on the association between gut microbiota and autoimmune diseases of the nervous system is still in its preliminary stage,and the mechanism of its influence on autoimmune diseases of the nervous system remains unclear.By reviewing related articles on gut microbiota and autoimmune diseases of the nervous system in recent years,this article elaborates on the interaction between gut microbiota and autoimmune diseases of the nervous system and the current research status of the treatment of autoimmune diseases of the nervous system by targeting gut microbiota.
作者
刘倩
胡天芹
王成斌
赵文娟
LIU Qian;HU Tianqin;WANG Chengbin;ZHAO Wenjuan(Department of Neurology,Tianjin Huanhu Hospital/Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease,Tianjin 300060,China;Department of Neurology,Hotan Regional People's Hospital,Hotan,Xinjiang 800848,China)
出处
《国际神经病学神经外科学杂志》
2024年第3期81-89,共9页
Journal of International Neurology and Neurosurgery
基金
天津市医学重点学科(专科)建设项目资助(TJYXZDXK⁃052B)
天津市教育委员会自然科学项目(2023KJ061)
新疆维吾尔自治区卫生健康委科技项目(WJWY202417)。
关键词
神经系统自身免疫性疾病
肠道菌群
炎症
autoimmune diseases of the nervous system
gut microbiota
inflammation
