摘要
目的探讨发热患儿的血清白蛋白与球蛋白比值(A/G)对预测川崎病(KD)发病风险的价值。方法采用单中心回顾性队列设计,基于某三甲医院大数据平台,收集432例0~16岁发热患儿的临床与实验室检查数据,根据其血清A/G的四分位数及中位数将其分为4组,分析A/G与发热患儿KD发病的相关性。结果432例发热患儿KD的总发病率为14.4%(62/432)。A/G与KD的发病呈负相关,每增加0.1的A/G,KD的发病风险降低18%(OR=0.82,95%CI 0.76~0.88,P<0.001)。亚组分析显示,不同年龄、性别及生化指标的患儿,A/G与KD发病之间的负相关趋势均一致。结论A/G可能是预测发热患儿KD发病的有效生物学标志物。随着A/G的上升,KD的发病风险逐渐降低。这一发现对KD的早期诊断和风险评估具有潜在的临床应用价值。
Objective To evaluate the predictive value for serum albumin-globulin ratio(A/G)for the risk of Kawasaki disease(KD)in febrile children.Methods In this single-center retrospective cohort study,the big-data platform of a certain thirdtier A-level hospital was employed.Clinical and laboratory data of 432 febrile children aged 0-16 were collected.The children were divided into 4 groups based on the quartiles and median of their serum A/G ratios.The correlation between the A/G and the risk of KD was analyzed.Results The total incidence rate of KD in 432 children with fever was 14.4%(62/432).A significant negative correlation was observed between the A/G and the risk of KD.For each increase of 0.1 in the A/G,the risk of KD was decreased by 18%(OR=0.82,95%CI 0.76-0.88,P<0.001).Subgroup analysis showed a consistent negative correlation between the A/G and KD risk across different ages,genders,and biochemical markers.Conclusions A/G may be a useful biomarker for assessing the risk of KD in febrile children.As the A/G increases,the risk of KD is gradually decreased.This finding has potential clinical application value for early diagnosis and risk assessment of KD.
作者
李海凤
张萍萍
李云艳
陈壮桂
钟贵芳
LI Haifeng;ZHANG Pingping;LI Yunyan;CHEN Zhuanggui;ZHONG Guifang(Department of Pediatrics,the Third Affi liated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Intensive Care Medicine,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China)
出处
《新医学》
CAS
2024年第7期512-519,共8页
Journal of New Medicine
基金
国家自然科学基金(32370191)
广东省自然科学基金(2019A1515011441)。
