摘要
目的:探讨血清抗桥粒芯蛋白1(Dsg1)、抗桥粒芯蛋白3(Dsg3)及抗表皮基底膜抗原180抗体(BP180)在口腔自身免疫性大疱病(ABD)诊断中应用价值。方法:选取2020年1月—2022年1月我院收治的152例口腔ABD患者(ABD组)、152例口腔溃疡患者(溃疡组)及152例健康人群(对照组),比较各组及不同病情程度患者血清Dsg1、Dsg3、BP180,统计血清Dsg1、Dsg3、BP180检出口腔ABD情况,应用Spearman分析血清Dsg1、Dsg3、BP180与病情程度关系,采用受试者工作特征曲线(ROC)分析血清Dsg1、Dsg3、BP180及联合诊断口腔ABD价值。结果:ABD组血清Dsg1、Dsg3、BP180大于溃疡组、对照组(P<0.05);血清Dsg1阳性检出口腔ABD 134例,Dsg3阳性检出口腔ABD 138例,BP180阳性检出口腔ABD 128例,血清Dsg1阳性、Dsg3阳性联合BP180阳性检出口腔ABD 150例;不同病情患者间血清Dsg1、Dsg3、BP180比较显示:重度>中度>轻度,两两比较差异均有统计学意义(P<0.05);血清Dsg1、Dsg3、BP180与口腔ABD患者病情程度呈正相关(P<0.05);血清Dsg1、Dsg3、BP180诊断口腔ABD的ROC曲线下面积分别为0.941、0.954、0.934,三者联合诊断口腔ABD的ROC曲线下面积为0.993;三者联合的特异度、准确度高于单一指标的灵敏度、准确度。结论:血清Dsg1、Dsg3、BP180与口腔ABD及其病情严重程度有关,三者联合诊断口腔ABD具有较高的灵敏度、特异度、准确率,可作为口腔ABD诊断和病情评估的标志物。
Objective:To investigate the application value of serum anti-bridging granule core protein 1(Dsg1),anti-bridging granule core protein 3(Dsg3)and anti-epidermal basement membrane antigen 180 antibody(BP180)in the diagnosis of oral autoimmune bullous diseases(ABD).Methods:152 patients with oral ABD(ABD group),152 patients with oral ulcer(ulcer group)and 152 healthy people(control group)were selected to our hospital from January 2020 to January 2022;serum Dsg1,Dsg3 and BP180 were compared among the groups and patients with different degrees of disease,serum Dsg1,Dsg3 and BP180 were counted to detect oral ABD;Spearman analysis was applied to analyze the relationship between serum Dsg1,Dsg3,BP180 and the degree of disease;the value of serum Dsg1,Dsg3,BP180 and combined diagnosis of oral ABD was analyzed by subject operating characteristic curve(ROC).Results:Serum Dsg1,Dsg3 and BP180 were greater in the ABD group than in the ulcer and control groups(P<0.05).134 cases of oral ABD were detected by positive serum Dsg1,138 cases of oral ABD were detected by positive Dsg3,128 cases of oral ABD were detected by positive BP180,and oral ABD was detected by positive serum Dsg1,positive Dsg3 combined with positive BP180150 cases;serum Dsg1,Dsg3,BP180:severe>moderate>mild,the difference between two comparisons was statistically significant(P<0.05);serum Dsg1,Dsg3,BP180 were positively correlated with the degree of oral ABD patients(P<0.05).The area under the ROC curve for the diagnosis of oral ABD with serum Dsg1,Dsg3 and BP180 was 0.941,0.954 and 0.934,respectively,and the area under the ROC curve for the diagnosis of oral ABD with the combination of the three was 0.993;the sensitivity and accuracy of the combination of the three were higher than those of the single index.Conclusion:Serum Dsg1,Dsg3 and BP180 are related to oral ABD and its disease severity,and the combination of the three has high sensitivity,specificity and accuracy in the diagnosis of oral ABD,which can be used as a marker for the diagnosis and disease assessment of oral ABD.
作者
赵刚
ZHAO Gang(Department of Stomatology,Ji’nan Integrated Traditional Chinese and Western Medicine Hospital,Ji’nan City,Shandong Province 271100)
出处
《医学理论与实践》
2024年第16期2719-2722,共4页
The Journal of Medical Theory and Practice
关键词
血清抗桥粒芯蛋白1
抗桥粒芯蛋白3
BP180
自身免疫性大疱病
诊断价值
Serum anti-bridging granule core protein 1
Anti-bridging granule core protein 3
BP180
Autoimmune bullous disease
Diagnostic value
