摘要
银屑病是一种病程久、病机复杂且易反复发作的慢性炎症性疾病,是临床亟待解决的疑难皮肤病。随着中药对银屑病的深入研究,诸多从NLRP3炎症小体角度开展研究中药治疗银屑病的作用机制,对提高银屑病治疗的准确性、多样性和降低药物的副作用具有重要意义。中药有效成分黄酮类、萜类、酚类等化合物及中药复方通过干预NLRP3炎症小体活化,可有效抑制胱天蛋白酶-1激活和促炎症细胞因子的成熟与分泌,诱导自噬、调控细胞焦亡和抑制角质形成细胞异常增殖,减轻银屑病皮损中炎症反应,从而改善银屑病病变。本文综述近年来中药调控NLRP3炎症小体治疗银屑病的研究进展,重点介绍中药单体有效成分及中药复方对NLRP3炎症小体活化的抑制作用及其相关机制,并探讨中药在治疗银屑病中的临床应用及前景,以期为中药调控NLRP3炎症小体治疗银屑病的深入研究和应用开发提供新的思路和方法。
Psoriasis is a chronic inflammatory disease with a long course,complex pathogenesis,and easy recurrence,it is a difficult skin disease that urgently needs to be solved in clinical practice.With the in-depth study of traditional Chinese medicine on psoriasis,it is of great significance to carry out research on the mechanism of traditional Chinese medicine in the treatment of psoriasis from the perspective of NLRP3 inflammasome,which can improve the accuracy and diversity of psoriasis treatment,and reduce the side effects of drugs.The effective components of traditional Chinese medicine,such as flavonoids,terpenoids,phenols,and other compounds,as well as traditional Chinese medicine compounds,can effectively inhibit the activation of NLRP3 inflammasome by interfering with it,inhibit the activation of cystenine aspartic acid specific protease-1 and the maturation and secretion of pro-inflammatory cytokines,induce autophagy,regulate pyroptosis,and inhibit the abnormal proliferation of keratinocytes,reduce the inflammatory response in psoriatic lesions,and thereby improve the pathological changes of psoriasis.This article reviews the research progress in the regulation of NLRP3 inflammasomes by traditional Chinese medicine in the treatment of psoriasis in recent years,with a focus on the inhibitory effects and related mechanisms of traditional Chinese medicine monomers and compound formulas on the activation of NLRP3 inflammasomes.It also explores the clinical application and prospects of traditional Chinese medicine in the treatment of psoriasis,aiming to provide new ideas and methods for the in-depth research and application development of traditional Chinese medicine regulation of NLRP3 inflammasomes in the treatment of psoriasis.
作者
张鑫妍
刘闯
安月鹏
杨素清
ZHANG Xinyan;LIU Chuang;AN Yuepeng;YANG Suqing(Graduate School,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Depar-tment of Dermatology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)
出处
《中国医药导报》
CAS
2024年第19期40-45,共6页
China Medical Herald
基金
国家自然科学基金资助项目(81973846)
国家自然科学基金青年科学基金资助项目(81904201)
黑龙江省自然科学基金项目(LH2019H108)。
关键词
NLRP3
炎症小体
银屑病
中药
NLRP 3
Inflammasome
Psoriasis
Traditional Chinese medicine
