摘要
酒精是中枢神经系统的抑制剂,长期大量饮酒会形成酒精依赖。酒精依赖是一种复杂而严重精神疾病,可导致日常身体、心理和社会功能的紊乱。目前,酒精依赖患病率约为2.6%,临床缺乏有效的预防策略、治疗措施和康复方案是导致酒精依赖全球健康负担不断增加的主要因素。长期反复饮酒和戒断可引起大脑结构和功能改变,造成神经心理认知功能损害,严重者可导致痴呆,严重危害人类的身心健康。酒精依赖造成的认知损害病因复杂,其中氧化应激在酒精依赖认知功能损害中起着关键作用。本综述针对酒精依赖所致认知损害与氧化应激的关系进行文献综述,以期为酒精依赖所致认知功能障碍的诊断和治疗提供一定借鉴。
Alcohol is a depressant of the central nervous system,and long-term heavy drinking can lead to alcohol dependence(AD).Alcohol dependence is a complex and serious mental illness that can lead to disturbances in daily physical,mental and social functioning.Currently,the prevalence of alcohol dependence is approximately 2.6%,and the lack of effective clinical prevention strategies,treatment,and rehabilitation options is a major factor contributing to the growing global health burden of alcohol dependence.Long-term repeated drinking and withdrawal can cause changes in brain structure and function,cause neuropsychological cognitive function damage,and lead to dementia in severe cases,which seriously endangers human physical and mental health.The etiology of cognitive impairment caused by alcohol dependence is complex,and oxidative stress plays a key role in the cognitive impairment of alcohol dependence.This review focuses on the relationship between cognitive impairment caused by alcohol dependence and oxidative stress,in order to provide some references for the diagnosis and treatment of cognitive dysfunction caused by alcohol dependence.
作者
穆迪(综述)
苏中华(审校)
MU Di;SU Zhonghua(School of Mental Health,Jining Medical University,Jining 272013,China;Alcohol Dependence Division,Shandong Daizhuang Hospital,Jining 272051,China)
出处
《济宁医学院学报》
2024年第4期346-348,共3页
Journal of Jining Medical University
基金
山东省医药卫生科技发展计划项目(20200309418)。
关键词
酒精依赖
认知损害
氧化应激
Alcohol dependence
Cognitive impairment
Oxidative stress
