摘要
目的探讨炙甘草汤对顽固性复发性口腔溃疡患者的疗效。方法按照随机数字表法分配原则将196例2019年1月—2021年12月该院收治的复发性口腔溃疡患者分为对照组(98例)和治疗组(98例)。对照组给予复合维生素B片、维生素C片、西地碘片进行治疗,治疗组在对照组基础上给予炙甘草汤进行治疗,两组均持续治疗2周,并随访1年。比较两组治疗2周后的疗效,临床症状改善情况及复发情况,治疗前、治疗2周后的中医证候积分、疼痛程度、睡眠质量、生活质量、炎症、免疫指标水平及治疗期间的安全性情况。结果与对照组治疗2周后的总有效率(84.69%,83/98)比较,治疗组总有效率更高(93.88%,92/98)(P<0.05)。与对照组比较,治疗组溃疡疼痛改善时间、溃疡愈合时间更短(P<0.05);与对照组随访期间的总复发率比较(13.27%,13/98),治疗组总复发率(5.10%,5/98)更低(P<0.05)。治疗2周后,两组溃疡隐痛、反复发作、口干口苦、胃脘痞闷、视觉模拟评分法(VAS)、匹兹堡睡眠质量量表(PSQI)评分、全血CD_(8)^(+)、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)水平与治疗前比较降低,治疗组更低(P<0.05);两组生存质量测定量表(QOL-100)评分、全血CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平与治疗前比较升高,治疗组更高(P<0.05)。治疗组和对照组治疗期间均未发生恶心呕吐、皮疹、头晕等情况。结论炙甘草汤可有效调节顽固性复发性口腔溃疡患者炎症及免疫指标水平,减轻机体炎症,改善免疫功能,并可改善疼痛程度、睡眠和生活质量,进而可促进患者中医证候及临床症状的改善,预防复发,疗效显著,安全性良好。
Objective To investigate the curative effect of Zhigancao Decoction(炙甘草汤)on patients with refractory recurrent oral ulcer.Methods A hundred and ninety-six patients with recurrent oral ulcer admitted to the hospital were divided into the control group(98 cases)and the treatment group(98 cases)from January 2019 to December 2021 by the distribution principle of random number table.The control group was treated with compound vitamin B tablets,vitamin C tablets and Cydiodine Tablets.The treatment group was treated with Zhigancao Decoction on the basis of the control group.Both groups were treated for 2 weeks and followed up for 1 year.The curative effect after 2 weeks of treatment,the clinical symptom improvement and recurrence,the scores of traditional Chinese medicine symptoms,pain degree,sleep quality,quality of life,the levels of inflammation,immune indexes and the safety during treatment were compared between the two groups.Results Compared with the total effective rate(84.69%,83/98)of the control group after 2 weeks of treatment,the total effective rate of the treatment group was higher(93.88%,92/98)(P<0.05).Compared with those of the control group,the times of ulcer pain improvement and ulcer healing in the treatment group were shorter(P<0.05).Compared with the total recurrence rate of the control group during the followed-up period(13.27%,13/98),the total recurrence rate of the treatment group(5.10%,5/98)was lower(P<0.05).After 2 weeks of treatment,the scores of dull ulcer pain,repeated attacks,dry mouth and bitter mouth,abdominal distension,visual analogue scale(VAS)score,pittsburgh sleep quality scale(PSQI)score,the levels of whole blood CD_(8)^(+),the levels of serum tumor necrosis factor-α(TNF-α)and interleukin-2(IL-2)in the treatment group were lower than those before,the indexes of the treatment group were lower(P<0.05).The score of quality of life scale(QOL-100)and the levels of whole blood CD_(4)^(+)and CD_(4)^(+)/CD_(8)^(+)in the two groups were higher than those before,and the levels of the treatment group were higher(P<0.05).There was no nausea,vomiting,rash or dizziness in the treatment group and the control group during the treatment.Conclusion Zhigancao Decoction could effectively regulate the levels of inflammation and immune indicators in patients with refractory recurrent oral ulcer,reduce the body inflammation,improve the immune function,the degree of pain,sleep and quality of life,which could further promote the improvement of traditional Chinese medicine symptoms and clinical symptoms and prevent the recurrence,with significant effect and higher safety.
作者
刘云
肖菲
关振群
LIU Yun;XIAO Fei;GUAN Zhenqun(Department of Stomatology,The Eighth People′s Hospital of Qingdao,Qingdao 266000,Shandong,China;Department of Stomatology,Qingdao Hospital of Traditional Chinese Medicine(Haici Medical Group),Qingdao 266000,Shandong,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第8期110-113,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
口腔溃疡
顽固性
复发性
炙甘草汤
中医证候
炎症
免疫功能
oral ulcer
refractory
recurrent
Zhigancao Decoction(炙甘草汤)
traditional Chinese medicine symptoms
inflammation
immune function
