摘要
目的探讨丁苯酞注射液对大面积脑梗死患者神经递质、炎性因子及脑电图的影响。方法纳入2019年9月—2020年9月收治的120例大面积脑梗死患者,按照随机数字表分为对照组与观察组,每组60例。对照组采取常规治疗,观察组在常规治疗的基础上加用丁苯酞注射液,连续治疗2周。观察临床总有效率、神经递质[神经元特异性烯醇化酶(NSE)、神经肽Y(NPY)、脑源性神经营养因子(BDNF)]、炎性因子[蛋白磷脂酶A2(Lp-PLA2)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)]及脑电图慢波化比率。结果治疗后,观察组临床总有效率(81.67%vs 55.00%)明显高于对照组(P<0.01);观察组血清NSE[(10.22±1.30)mg/L vs(14.35±2.60)mg/L],NPY[(116.25±6.38)ng/L vs(150.17±8.22)ng/L]水平明显低于对照组(P<0.001),血清BDNF[(7.52±1.48)ng/mL vs(5.31±1.06)ng/mL]水平明显高于对照组(P<0.001);观察组血清Lp-PLA2[(25.47±4.13)μg/L vs(41.83±5.36)μg/L]、IL-6[(88.65±4.28)pg/L vs(101.39±6.10)pg/L]、hs-CRP[(4.10±0.62)ng/L vs(7.78±1.55)ng/L]水平明显低于对照组(P<0.001);观察组脑电图慢波化比率[(2.36±0.59)vs(4.27±1.16)]明显低于对照组(P<0.001)。结论丁苯酞注射液可改善神经递质水平,能抑制炎性反应,提高大面积脑梗死患者的临床疗效。
Objective To investigate the effects of butylphthalein injection on neurotransmitters,inflammatory factors and electroencephalogram in patients with large area cerebral infarction.Methods A total of 120 patients with large area cerebral infarction admitted to hospital from September 2019 to September 2020 were included and divided into control group and observation group according to random number table,with 60 cases in each group.The control group were given routine treatment,and the observation group were treated with butylphthalide injection on the basis of routine treatment.All patients were continuously treated for two weeks.And then,total clinical efficacy rate,neurotransmitters(neuron-specific enolase[NSE],neuropeptide Y[NPY],brain-derived neurotrophic factor[BDNF]),inflammatory factors(protein phospholipase A2[LP-PLA2],interleukin-6[IL-6]and hypersensitive C-reactive protein[hs-CRP])and slow-wave ratio of electroencephalogram were observed.Results After treatment,the total clinical efficacy rate(81.67%vs 55.00%)in the observation group was significantly higher than that in the control group(P<0.01).The serum levels of NSE([10.22±1.30]mg/L vs[14.35±2.60]mg/L),NPY([116.25±6.38]ng/L vs[150.17±8.22]ng/L)in the observation group were significantly lower than those in the control group(P<0.001),and the serum levels of BDNF([7.52±1.48]ng/mL vs[5.31±1.06]ng/mL)in the observation group were significantly higher than those in the control group(P<0.001).The serum levels of Lp-PLA2([25.47±4.13]μg/L vs[41.83±5.36]μg/L,IL-6[88.65±4.28]pg/L vs[101.39±6.10]pg/L,and hs-CRP[4.10±0.62]ng/L vs[7.78±1.55]ng/L)in the observation group were significantly lower than those in the control group(P<0.001).The slow-wave ratio of electroencephalogram([2.36±0.59]vs[4.27±1.16])in the observation group was significantly lower than that in the control group(P<0.001).Conclusion Butylphthalein injection can improve the levels of neurotransmitter,inhibit inflammatory response and improve the clinical efficacy of patients with large area cerebral infarction.
作者
邹昂儒
庞霖霖
钟才
周少旦
ZOU Angru;PANG Linlin;ZHONG Cai;ZHOU Shaodan(Department of Emergency,Ethnic Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001,Guangxi,China;Department of Neurology,Ethnic Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001,Guangxi,China)
出处
《右江医学》
2024年第7期613-617,共5页
Chinese Youjiang Medical Journal
基金
崇左市科技计划项目(崇科攻2019010)。
关键词
大面积脑梗死
丁苯酞注射液
神经递质
炎性因子
脑电图
large area cerebral infarction
butylphthalide injection
neurotransmitters
inflammatory factors
electroencephalogram
