摘要
目的:观察腹腔镜下低位直肠癌保肛术对老年低位直肠癌患者疼痛因子、应激反应指标及肠道功能的影响。方法:选择2022年1月—2023年1月枣庄市立医院收治的100例老年低位直肠癌患者作为研究对象,通过随机数表法分为对照组(n=50)和观察组(n=50)。对照组予以传统腹会阴联合切除术治疗,观察组予以腹腔镜下低位直肠癌保肛术治疗。比较两组疼痛因子、应激反应指标及肠道功能情况。结果:观察组术后1 d神经肽(NPY)及前列腺素E2(PGE2)低于对照组差异有统计学意义(P<0.05);术后1 d皮质醇(Cor)、醛固酮(ALD)、丙二醇(MDA)低于对照组,差异有统计学意义(P<0.05);观察组术后3个月肛管最大耐受容量(MTV)、肛管最大收缩压(MSP)、肛管静息压(ARP)高于对照组,差异有统计学意义(P<0.05);观察组术后3个月纪念斯隆—凯特林癌症中心(MSKCC)肠道功能问卷、癌症患者生活质量量表(EORTC QLQ-C30)评分高于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜下低位直肠癌保肛术对老年低位直肠癌患者疼痛因子、应激反应指标具有调节作用,能促进患者术后肠道功能恢复和提高生活质量。
Objective:To observe the effects of laparoscopic sphincter preservation surgery on pain factors,stress response indicators,and intestinal function in elderly patients with low rectal cancer.Method:100 elderly patients with low rectal cancer in Zaozhuang Municipal Hospital from January 2022 to January 2023 were randomly divided into two groups using a number table.50 cases in the control group were treated with traditional combined abdominal and perineal resection,while 50 cases in the observation group were treated with laparoscopic sphincter preservation surgery for low rectal cancer.The pain factors,stress response indicators,and intestinal function were compared between two groups.Result:The neuropeptide(NPY)and prostaglandin E2(PGE2)levels in the observation group were lower than those in the control group the first day after surgery,the differences were statistically significant(P<0.05)while cortisol(Cor),aldosterone(ALD),and propylene glycol(MDA)levels were lower than those in the control group the first day after surgery.The maximum tolerable volume(MTV),maximum systolic pressure(MSP),and resting pressure(ARP)of the anal canal in the observation group were higher than those in the control group the third month after surgery.The Memorial Sloan Kettering Cancer Center(MSKCC)Intestinal Function Questionnaire The quality of life scale(EORTC QLQ-C30)score of cancer patients was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Laparoscopic sphincter preservation surgery for low rectal cancer has a regulatory effect on pain factors and stress response indicators in elderly patients with low rectal cancer,which can promote postoperative recovery of intestinal function and improve the living quality.
作者
李挺
罗炜
杨朋来
LI Ting;LUO Wei;YANG Penglai(Zaozhuang Municipal Hospital,Zaozhuang 277100,China;不详)
出处
《中外医学研究》
2024年第21期29-32,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
低位直肠癌
腹腔镜下低位直肠癌保肛术
疼痛因子
应激反应
肠道功能
Low rectal cancer
Laparoscopic sphincter preservation surgery for low rectal cancer Pain factors
Stress response
Intestinal function
