摘要
目的:研究注射用鼠神经生长因子联合高压氧对早产脑损伤患儿新生儿神经行为(NABA)评分及Tau蛋白、Toll样受体9(TLR9)mRNA相对表达水平的影响。方法:以2021年10月—2022年10月我院收治的99例早产脑损伤患儿为研究对象,采用随机数字表法分为对照组(49例)和联合组(50例)。对照组采用高压氧治疗,联合组采用注射用鼠神经生长因子联合高压氧治疗。比较两组临床疗效、NABA评分、大脑中动脉血流动力学指标[收缩期峰值流速(PSFV)、舒张末期血流速度(EDFV)、平均血流速度(Vm)、阻力指数(RI)]、血清指标[髓鞘碱性蛋白(MBP)、S100钙结合蛋白β(S100β)、Tau蛋白及TLR9 mRNA相对表达水平]、不良反应发生率。结果:联合组临床总有效率高于对照组(P<0.05);联合组NABA评分高于对照组(P<0.05);联合组大脑中动脉PSFV、EDFV、Vm高于对照组,RI低于对照组(P<0.05);联合组血清MBP、S100β、Tau蛋白及TLR9 mRNA相对表达水平低于对照组(P<0.05);联合组不良反应总发生率高于对照组,但差异无统计学意义(P>0.05)。结论:采用注射用鼠神经生长因子与高压氧联合治疗早产脑损伤患儿可提高临床疗效,减轻患儿神经行为异常,促进脑血流动力学及神经功能改善。
Objective:To study the effects of mouse nerve growth factor for injection combined with hyperbaric oxygen on Neonatal behavioral neurological assessment(NABA)score and relative expression levels of Tau protein and Toll-like receptor 9(TLR9)mRNA in premature infants with brain injury.Methods:Ninety-nine children with premature brain injury admitted to our hospital from October 2021 to October 2022 were enrolled in the study.They were divided into control group(49 children)and combined group(50 children)by random number table method.The control group was treated with hyperbaric oxygen,and the combined group was treated with mouse nerve growth factor for injection combined with hyperbaric oxygen.The clinical eficacy,NABA score,hemodynamic indexes of middle cerebral artery[peak systolic velocity(PSFV),end diastolic velocity(EDFV),mean blood flow velocity(Vm),resistance index(RI)],serum indexes[myelin basic protein(MBP),S100 calcium binding proteinβ(S100β),Tau protein and TLR9 mRNA relative expression levels J and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the combined group was higher than that of the control group(P<0.05).The NABA score of the combined group was higher than that of the control group(P<0.05).The middle cerebral artery PSFV,EDFV and Vm in the combined group were higher than those in the control group,and RI was lower than that in the control group(P<0.05).The relative expression levels of serum MBP,S100β,Tau protein and TLR9 mRNA in the combined group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the combined group was higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion:The combination of mouse nerve growth factor for injection and hyperbaric oxygen in the treatment of premature infants with brain injury can improve the clinical efficacy,reduce the neurobehavioral abnormalities,and promote the improvement of cerebral hemodynamics and neurological function.
作者
张磊
黄玉焕
李莹
ZHANG Lei;HUANG Yuhuan;LI Ying(Department of Neonatal Intensive Care,the First People's Hospital of Nanyang City,Nanyang 473000,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第7期1260-1263,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
注射用鼠神经生长因子
高压氧
早产儿脑损伤
新生儿神经行为评分
Mouse nerve growth factor for injection
Hyperbaric oxygen
Premature infant brain injury
Neonatal behavioral neurological assessment
