摘要
目的探究孕早期监测B淋巴细胞活化因子(BAFF)、抗米勒管激素(AMH)、白介素-2(IL-2)对复发性流产患者流产再发生的临床预测价值。方法选取2019年9月至2023年6月上海健康医学院附属崇明医院收治的100例复发性流产患者作为研究对象并纳入观察组,根据患者早期妊娠情况分为非流产组(n=65)和流产组(n=35);选取同期同院100例产检健康的孕妇作为对照组。比较各组血清BAFF、AMH、IL-2水平,分析BAFF、AMH、IL-2水平预测流产再发生的临床价值。采用Logistic回归分析影响复发性流产患者流产再发生的因素。结果观察组BAFF、IL-2水平比对照组高,AMH水平比对照组低(P<0.05)。流产组BAFF、IL-2水平比非流产组高,AMH水平比非流产组低(P<0.05)。流产组孕次、流产≥3次比例高于非流产组(P<0.05)。绘制受试者工作特征(ROC)曲线发现,BAFF、AMH、IL-2水平预测患者发生再流产的曲线下面积(AUC)分别是0.809、0.821、0.803,三者联合检测的AUC为0.919,均优于各自单独检测(Z=1.920、1.974、2.298,P<0.05)。多因素Logistic回归发现,BAFF、IL-2是影响患者发生再流产的危险因素,AMH为保护因素(P<0.05)。结论复发性流产患者BAFF、IL-2水平升高,AMH水平降低,且三者联合检测有助于早期预测流产再发生,具有一定的诊断价值。
Objective To explore the clinical value of monitoring B cell lymphocyte activating factor(BAFF),anti-Müllerian hormone(AMH)and interleukin-2(IL-2)in early pregnancy in predicting the recurrence of abortion in patients with recurrent abortion.Methods A total of 100 patients with recurrent abortion admitted to Chongming Hospital Affiliated to Shanghai University of Health and Medical Sciences from September 2019 to June 2023 were selected as the study subjects and included in the observation group.According to the early pregnancy status of the patients,they were divided into non-abortion group(n=65)and abortion group(n=35).A total of 100 healthy pregnant women with antenatal examination in the same hospital during the same period were selected as the control group.The levels of serum BAFF,AMH and IL-2 in each group were compared,and the clinical value of BAFF,AMH and IL-2 levels in predicting the recurrence of abortion was analyzed.Logistic regression analysis was used to analyze the factors affecting the recurrence of abortion in patients with recurrent abortion.Results The levels of BAFF and IL-2 in the observation group were higher than those in the control group,and the level of AMH was lower than that in the control group(P<0.05).The levels of BAFF and IL-2 in the abortion group were higher than those in the non-abortion group,and the level of AMH was lower than that in the non-abortion group(P<0.05).The proportion of gravidity and abortion≥3 times in abortion group was higher than that in non-abortion group(P<0.05).The receiver operating characteristic(ROC)curve was drawn,and found that the area under the curve(AUC)of BAFF,AMH and IL-2 levels in evaluating patients with recurrent abortion was 0.809,0.821 and 0.803,respectively.The AUC of the combined detection of the three was 0.919,which was better than that of the individual detections(Z=1.920,1.974,2.298,P<0.05).Multivariate Logistic regression analysis showed that BAFF and IL-2 were risk factors for recurrent abortion,and AMH was a protective factor(P<0.05).Conclusions The levels of BAFF and IL-2 in patients with recurrent abortion increased,and the level of AMH decreased.The combined detection of the three is helpful to predict the recurrence of abortion in the early stage,and has certain diagnostic value for the recurrence of abortion.
作者
曹作增
张蕾
张宇
李俊
CAO Zuozeng;ZHANG Lei;ZHANG Yu;LI Jun(Department of Gynecology,Chongming Hospital Affiliated to Shanghai University of Health and Medical Sciences,Shanghai 202150,China)
出处
《中国性科学》
2024年第8期86-90,共5页
Chinese Journal of Human Sexuality
关键词
复发性流产
B淋巴细胞活化因子
抗苗勒管激素
白介素-2
流产再发生
Recurrent abortion
B cell lymphocyte activating factor
Anti-Müllerian hormone
Interleukin-2
Recurrence of abortion
