摘要
近年来,随着大众对自身的健康意识的不断提高,多酚类物质对机体的有益影响逐渐被人们认识。国内外学者对于多酚的研究颇多,目前研究,证实多酚类物质由于自身的化学性质,有较好的抗炎抗氧化作用,对许多疾病,例如:癌症、糖尿病和结肠炎等均有改善作用。中国是全球最大的亚麻生产和消费国家之一。其中亚麻籽中存在大量的亚麻木酚素,亚麻木酚素也是多酚类物质的一种,其对机体的影响不言而喻。亚麻木酚素作为一种对众多疾病的都有一定的辅助治疗的物质,表现出巨大的发展潜力。因此,本文对亚麻的来源、代谢过程、生物作用进行了描述,并从与亚麻木酚素相关信号通路的角度,全面综述亚麻木酚素干预疾病的机制。研究发现,亚麻籽木酚素可通过直接调节基因表达或间接调节信号通路的方式,促进机体健康。此外,亚麻木酚素还能根据特定的生理条件发挥不同的作用。
In recent years,the growing public awareness of personal health has sparked a surge in interest in the beneficial effects of polyphenols on the human organism.Extensive research by domestic and international scholars has established that polyphenols,due to their unique chemical properties,exhibit remarkable anti-inflammatory and antioxidant properties,leading to improvements in various diseases,including cancer,diabetes,and colitis.Notably,China stands as one of the world’s largest producers and consumers of flax,a crop rich in lignans,a subclass of polyphenols.These flax lignans possess significant effects on the body,demonstrating immense potential for therapeutic applications.This paper delves into the origins,metabolic processes,and health benefits of flax lignans in China.It offers a comprehensive review of the mechanisms underlying flax lignans role in disease intervention,focusing on their interactions with relevant signalling pathways.Our findings suggest that flaxseed lignans can promote organismic health by either directly modulating gene expression or indirectly regulating signalling pathways.Furthermore,flaxseed lignans can exhibit diverse effects depending on specific physiological conditions.
作者
颜雪茹
何恩鹏
蔡啸镝
YAN Xue-Ru;HE En-Peng;CAI Xiao-Di(Key Laboratory of Human Exercise Science College of Life Sciences,School of Physical Education Xinjiang Normal University,Urumqi 830054,Xinjiang,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2024年第8期1057-1064,共8页
Chinese Journal of Biochemistry and Molecular Biology
基金
师范认证背景下体育教育专业“体育教学虚拟教研室”建设实践研究(No.SDJG2022-5)资助。
关键词
亚麻木酚素
多酚
抗炎抗氧化
信号通路
flaxseed lignans
polyphenols
anti-inflammatory and antioxidant
signalling pathways
