摘要
目的分析孟鲁司特钠结合普米克令舒对支气管哮喘急性发作患儿的治疗效果。方法选取我院2022年1月至2023年4月期间收治的80例支气管哮喘急性发作患儿,按数字随机表法分为两组,即对照组40例,采用普米克令舒治疗;观察组40例,基于对照组用药方案上采用孟鲁司特钠;对比两组治疗效果、免疫功能、炎症表达等。结果观察组治疗效果总有效率97.50%高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组治疗后免疫球蛋白IgA、IgG、IgM水平高于对照组,血清白细胞介素(IL)-6、IL-17、嗜酸性粒细胞(EOS)水平低于对照组(P<0.05)。两组不良反应发生率比较无差异(P>0.05)。结论孟鲁司特钠结合普米克令舒治疗支气管哮喘急性发作患儿取得理想效果,且能改善机体免疫功能,降低血清炎症表达,值得临床应用。
Objective To analyze the therapeutic effect of montelukast sodium combined with pamicrinosul in children with acute exacerbation of bronchial asthma.Methods A total of 80 children with acute exacerbation of bronchial asthma admitted to our hospital from January 2022 to April 2023 were selected and divided into two groups according to the numerical random table method,namely 40 cases in the control group,and pramiclosiol was used for treatment.In the observation group,40 cases were used on the drug regimen of the control group.The treatment effect,immune function,and inflammatory expression of the two groups were compared.Results The total effective rate of treatment effect in the observation group was 97.50%higher than that of 80.00%in the control group,and the difference was statistically significant(P<0.05).The levels of immunoglobulin IgA,IgG and IgM in the observation group were higher than those in the control group,and the levels of serum interleukin(IL)-6,IL-17 and eosinophil(EOS)were lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Montelukast sodium combined with pramicrinole in the treatment of children with acute exacerbation of bronchial asthma has achieved ideal results,and can improve the body's immune function and reduce serum inflammation expression,which is worthy of clinical application.
作者
赵晨
ZHAO Chen(Department of Pharmacy,Children's Hospital Affiliated of Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou 450000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第8期35-36,59,共3页
Journal of Rare and Uncommon Diseases
