摘要
目的分析对于急性支气管炎联合使用福尔可定、头孢唑林钠的疗效。方法70例急性支气管炎患者,应用抽签法分为对照组与观察组,每组35例。对照组给予头孢唑林钠治疗,观察组给予福尔可定+头孢唑林钠治疗。比较两组患者治疗前后的血清炎症因子[白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、降钙素原(PCT)]、不良反应发生情况、症状缓解时间、治疗效果、肺功能[用力肺活量(FVC)、呼吸时间比(Ti/Te)、潮气量(VT)、呼气高峰流量(PEFR)]。结果治疗后,观察组IL-4(1.76±0.21)pg/ml、IL-6(23.65±2.31)ng/L、PCT(3.19±0.21)μg/L均低于对照组的(3.18±0.21)pg/ml、(37.63±2.01)ng/L、(6.36±0.22)μg/L(P<0.05)。两组不良反应发生率均为5.71%,比较无明显差异(P>0.05)。观察组咳嗽、肺部啰音、发热、咯痰等缓解时间分别为(4.31±1.35)、(3.64±1.54)、(2.48±0.21)、(4.32±1.01)d,相对于对照组的(5.67±1.78)、(4.41±1.51)、(3.55±1.63)、(5.31±1.03)d较短(P<0.05)。观察组治疗总有效率97.14%相对于对照组的74.29%较高(P<0.05)。治疗后,观察组FVC(2.76±0.21)L、Ti/Te(76.03±0.21)%、VT(9.37±0.21)ml/kg、PEFR(3.78±0.21)L/s均高于对照组的(2.36±0.12)L、(62.61±0.21)%、(7.26±0.33)ml/kg、(2.65±0.21)L/s(P<0.05)。结论将福尔可定、头孢唑林钠联合应用到急性支气管炎的治疗中效果明显,不仅可以改善患者炎症因子与肺功能,也能使整体疗效提升,用药安全性高。
Objective To analyze the efficacy of pholcodine combined with cefazolin sodium in the treatment of acute bronchitis.Methods A total of 70 patients with acute bronchitis were included.The patients were divided into a control group and an observation group by lottery method,with 35 cases in each group.The control group was treated with cefazolin sodium,and the observation group was treated with pholcodine+cefazolin sodium.Patients in both groups were compared in terms of serum inflammatory factors[interleukin-4(IL-4),interleukin-6(IL-6),procalcitonin(PCT)],occurrence of adverse reactions,symptom remission time,therapeutic effect,lung function[forced vital capacity(FVC),respiratory time ratio(Ti/Te),tidal volume(VT),and peak expiratory flow rate(PEFR)]before and after treatment.Results After treatment,the observation group had IL-4 of(1.76±0.21)pg/ml,IL-6 of(23.65±2.31)ng/L and PCT of(3.19±0.21)μg/L,which were lower than(3.18±0.21)pg/ml,(37.63±2.01)ng/L and(6.36±0.22)μg/L in the control group(P<0.05).The incidence of adverse reactions in both groups was 5.71%,with no significant difference(P>0.05).The remission time of cough,pulmonary rale,fever and expectoration in the observation group were(4.31±1.35),(3.64±1.54),(2.48±0.21)and(4.32±1.01)d,which were shorter than(5.67±1.78),(4.41±1.51),(3.55±1.63),(5.31±1.03)d in the control group(P<0.05).The total effective rate of the observation group was 97.14%,which was higher than 74.29%of the control group(P<0.05).After treatment,the observation group had FVC of(2.76±0.21)L,Ti/Te of(76.03±0.21)%,VT of(9.37±0.21)ml/kg and PEFR of(3.78±0.21)L/s,which were higher than(2.36±0.12)L,(62.61±0.21)%,(7.26±0.33)ml/kg and(2.65±0.21)L/s in the control group(P<0.05).Conclusion Combination of pholcodine and cefazolin sodium has remarkable effect on the treatment of acute bronchitis,which can not only improve inflammatory factors and lung function of patients,but also improve the overall treatment effect with high medication safety.
作者
刘顺华
王彬
钟林鸿
LIU Shun-hua;WANG Bin;ZHONG Lin-hong(Ruijin Maternal and Child Health Care Hospital,Ruijin 342500,China)
出处
《中国实用医药》
2024年第15期94-97,共4页
China Practical Medicine
基金
福尔可定联合头孢唑林钠治疗急性支气管炎的效果临床研究(项目编号:GZ2023ZSF561)。
