摘要
目的:分析胎盘生长因子(PLGF)与子宫动脉血流动力学参数间的相关性,并评估其对子痫前期的预测效能。方法:选取南阳医学高等专科学校附属中医院2021年1月—2023年5月收治的122例妊娠期高血压(HDP)患者为研究对象,根据病情严重程度将入组患者分为高危组(32例)、中危组(45例)及低危组(45例),比较3组患者PLGF和子宫动脉血流动力学参数水平,经Pearson相关性系数检验PLGF与子宫动脉血流动力学参数间的相关性。根据HDP患者子痫前期发生情况将其分为子痫前期组和非子痫前期组,比较2组患者PLGF及子宫动脉血流动力学参数,绘制受试者工作特征曲线(ROC)评估PLGF对子痫前期的预测效能。结果:高危组PLGF为(40.24±10.31)pg/mL,低于中危组的(48.24±10.36)pg/mL和低危组的(55.62±15.45)pg/mL,子宫动脉搏动指数(PI)、阻力指数(RI)、收缩期峰值及舒张末期流速之比(S/D)分别为(1.66±0.23)、(0.77±0.23)、(3.39±0.27)均高于中危组的(1.08±0.21)、(0.56±0.14)、(2.92±0.36)和低危组的(0.84±0.16)、(0.39±0.15)、(2.21±0.36),差异均有统计学意义(P<0.05)。相关性分析显示,PLGF与PI、RI、S/D呈负相关。122例HDP患者中,41例发生子痫前期,患病率为33.61%。子痫前期组PLGF为(60.41±10.27)pg/mL,低于非子痫前期组的(55.16±10.71)pg/mL,PI、RI、S/D分别为(2.05±0.36)、(0.83±0.21)、(4.12±1.25),均高于非子痫前期组的(1.71±0.43)、(0.71±0.22)、(3.44±0.47),差异均有统计学意义(P<0.05)。PLGF预测子痫前期的灵敏度、特异度分别为80.23%、79.36%,截断值为57.79 ng/mL,AUC为0.856(95%CI=0.802~0.911)。结论:PLGF水平随HDP患者PI、RI、S/D升高而降低,动态监测PLGF水平能早期预测子痫前期。
Objective:To analyze the correlation between placental growth factor(PLGF)and uterine artery hemodynamic parameters and its predictive efficacy for preeclampsia.Methods:This article is a retrospective study,with cases included from January 2021 to May 2023.122 patients with hypertensive disorders of pregnancy(HDP)were divided into a high-risk group(32 cases),a medium risk group(45 cases),and a low risk group(45 cases)based on the severity of their condition.The differences in PLGF and uterine artery hemodynamic parameters among the three groups of patients were compared.The Pearson correlation coefficient was used to test the correlation between PLGF and uterine hemodynamic parameters.Statistics were conducted on the occurrence of preeclampsia in the 122 HDP patients and they were divided into a preeclampsia group and a non-preeclampsia group.The differences in PLGF and uterine hemodynamic parameters between the two groups were compared.The predictive efficacy of PLGF on preeclampsia was verified through ROC and AUC observation.Results:After testing,the PLGF of the high-risk group was(40.24±10.31)pg/ml,lower than that of the medium risk group(48.24±10.36)pg/ml and the low risk group(55.62±15.45)pg/ml.The PI,RI,and S/D of uterine arteries in the high-risk group were(1.66±0.23),(0.77±0.23),and(3.39±0.27),respectively,which were higher than those in the medium risk group[(1.08±0.21),(0.56±0.14),(2.92±0.36)],and the low risk group[(0.84±0.16),(0.39±0.15),and(2.21±0.36)](P<0.05).The correlation coefficient test indicated that PLGF was negatively correlated with uterine artery hemodynamic parameters such as PI,RI,and S/D.Among the 122 HDP patients,41 developed preeclampsia,with the incidence of 33.61%.The PLGF of the preeclampsia group was(60.41±10.27)pg/ml,lower than that of the non preeclampsia group(55.16±10.71)pg/ml;PI,RI,and S/D were(2.05±0.36),(0.83±0.21),and(4.12±1.25),respectively,higher than those in the non preeclampsia group[(1.71±0.43),(0.71±0.22),and(3.44±0.47)](P<0.05).The predictive sensitivity and specificity of PLGF for preeclampsia were 80.23%and 79.36%,respectively,with a cutoff value of 57.79ng/ml and AUC=0.856(95%CI:0.802~0.911).Conclusion:PLGF will continuously decrease with the increase of PI,RI,and S/D in HDP patients,and dynamic monitoring of PLGF levels can achieve early prediction of preeclampsia.
作者
韩楠楠
HAN Nannan(Department of Gynecology,Affiliated Traditional Chinese Medicine Hospital of Nanyang Medical College,Nanyang,Henan 473000,China)
出处
《淮海医药》
CAS
2024年第4期364-367,共4页
Journal of Huaihai Medicine
基金
河南省医学科技攻关项目(LHGJ2021002173)。
关键词
子痫
妊娠期高血压
胎盘生长因子
子宫动脉血流动力学
预测效能
Eclampsia
Pregnancy induced hypertension
Placental growth factor
Uterine arterial hemodynamics
Predictive efficiency
