摘要
1例67岁男性患者因“阵发性抽搐发作2周余”入院,诊断为抗γ-氨基丁酸B型受体(GABA_(B)R)抗体相关脑炎。入院后给予免疫治疗,治疗过程中出现癫痫持续状态、肺部感染、低蛋白血症、凝血功能异常等。临床药师结合患者病情,在免疫治疗方案的选择上给予甲泼尼龙联合静脉注射免疫球蛋白,在需要抗感染治疗时给予美罗培南(1 g q8h ivgtt);应用多烯磷脂酰胆碱护肝,给予氨溴索联合布地奈德改善肺功能,应用低分子量肝素钙预防血栓形成,对患者的营养和电解质平衡方面进行监护,给予患者全程化监护,最终患者病情好转出院。
A 67-year-old male patient was admitted to the hospital because of paroxysmal limb convulsions for 2 weeks,and was diagnosed as anti-γ-aminobutyric acid B receptor encephalitis.He developed status epilepticus,pulmonary infection,hypoproteinemia,and coagulation disorder,etc during the immunotherapy after the admission.Based on the patient’s condition,clinical pharmacists suggested giving methylprednisolone and intravenous immunoglobulin for immunotherapy,meropenem(1 g q8h ivgtt)for anti-infective therapy,polyene phosphatidylcholine for liver damage,ambroxol combined with budesonide for improving lung function,and low molecular weight heparin calcium for prevention of thrombosis.The nutrition condition and electrolyte balance of the patient was also closely monitored by clinical pharmacists.Finally,the patient was discharged with improved condition after the whole-course pharmaceutical care.
作者
张璇
姜珊珊
焦秀秀
朱青霞
俞晓艳
ZHANG Xuan;JIANG Shan-shan;JIAO Xiu-xiu;ZHU Qing-xia;YU Xiao-yan(Department of Pharmacy,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011)
出处
《中南药学》
CAS
2024年第8期2217-2220,共4页
Central South Pharmacy
基金
上海市卫健委“医苑新星”青年医学人才培养资助计划。
关键词
抗GABABR抗体相关脑炎
全程化
药学监护
用药分析
anti-γ-aminobutyric acid B receptor encephalitis
whole-course
pharmaceutical care
medication analysis
