摘要
目的观察鼻炎3号方联合鼻负压置换治疗急性鼻窦炎(胆腑郁热证)患者的临床疗效。方法98例患者随机分为观察组与对照组各49例,对照组予鼻腔负压置换治疗,观察组在对照组基础上予鼻炎3号方治疗,治疗周期均为2周。观察中医证候疗效、中医证候积分、视觉模拟量表(VAS)评分、鼻腔鼻窦结局测试-20(SNOT-20)量表、Lund-Mackey评分、炎性指标、安全性评价。结果观察组总有效率为91.84%,高于对照组的71.43%(P<0.05)。疗程结束后,两组中医证候积分、VAS评分、SNOT-20量表、Lund-Mackey评分、炎性指标[C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞百分比(NEUT%)]均较治疗前下降(P<0.05),其中中医证候积分鼻涕、头痛、鼻分泌物、鼻黏膜充血4项,VAS评分脓涕项两组间差异无统计学意义(P>0.05),其余各项观察组下降程度更明显(P<0.05)。两组安全性指标差异无统计学意义(P>0.05)。结论鼻炎3号方联合鼻负压置换治疗急性鼻窦炎(胆腑郁热证)疗效显著,可有效改善中医证候,提高生活质量,减轻炎症反应,安全性良好。
Objective:To observe the clinical efficacy of the combined treatment with Rhinitis No.3 Decoction and nasal negative pressure displacement for acute sinusitis(pattern of stagnant heat in the gallbladder).Method:A total of 98 patients were randomly divided into an observation group and a control group,with 49 cases in each group.The control group received nasal negative pressure displacement,while the observation group received Rhinitis No.3 Decoction on the basis of the control group.The treatment period was 2 weeks for both groups.The therapeutic effect of traditional Chinese medicine syndrome,TCM syndrome score,VAS score,SNOT-20 scale,Lund-Mackey score,inflammatory indicators,and safety were observed.Results:The total effective rate of the observation group was 91.84%,which was higher than 71.43%of the control group(P<0.05).After treatment,the TCM syndrome scores,VAS scores,SNOT-20 scale,Lund-Mackey scores,and inflammatory indicators(CRP,WBC,NEUT%)of both groups decreased compared with before treatment(P<0.05).Among them,four items in the TCM syndrome scores,i.e.,the nasal mucus,headache,nasal secretions,and nasal mucosal congestion,as well as purulent mucus in the VAS score showed no statistically significant difference between the two groups(P>0.05),while the other scores showed a more significant decrease in the observation group(P<0.05).There was no statistically significant difference in safety indicators between the two groups(P>0.05).Conclusion:The combination of Rhinitis No.3 Decoction and nasal negative pressure displacement has a significant therapeutic effect on acute sinusitis(pattern of stagnant heat in the gallbladder),which can improve TCM syndrome,improve quality of life,reduce inflammatory reactions,and has good safety.
作者
刘静丹
谢梁震
王嘉乐
赵雨奇
周凌
Liu Jingdan;Xie Liangzhen;Wang Jiale;Zhao Yuqi;Zhou Ling(Heilongjiang University of Traditional Chinese Medicine,Heilongjiang,Harbin 150040,China)
出处
《中国中医急症》
2024年第8期1354-1357,1368,共5页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金项目(81874495)
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)。
关键词
急性鼻窦炎
鼻炎3号方
胆腑郁热证
负压置换
临床观察
Acute sinusitis
Rhinitis No.3 Decoction
Pattern of stagnant heat in the gallbladder
Negative pres⁃sure displacement
Clinical observation
