摘要
目的:探究高脂血症孕妇脂血标本生化检验时的影响及处理效果,分析高脂血症与不良妊娠结局关系。方法:回顾性收集2018年12月-2023年12月本院接受产前检查并分娩的高脂血症孕妇102例纳入高脂血症组,同期产前检查并分娩的正常孕妇102例纳入健康组。将观察组血液标本采取低温高速离心法处理,对比标本处理前后生化检验指标血肌酐(Cr)、血清碱性磷酸酶(ALP)、肌酸激酶同工酶(CK-MB)、空腹血糖(FBG)、天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)变化;对比两组不良母婴结局;采用受试者工作特征(ROC)曲线分析高脂血对不良妊娠结局的评估价值;采用Spearman相关性分析脂血与不良妊娠结局相关性。结果:高脂血症组血标本处理后Cr、ALP、CK-MB、FBG、AST和ALT水平均较处理前降低,且血TC、TG、HDL-C和LDL-C水平均高于健康组(均P<0.05)。不良妊娠结局高脂血症组(23.5%)高于健康组(6.9%)(P<0.05),但不同孕期诊断高血脂症孕妇其不良妊娠结局发生率未见差异(P>0.05);脂血检测评估不良妊娠结局的ROC曲线下面积为0.720、特异性57.2%、敏感度90.3%,孕妇血脂水平与母体、胎儿不良结局均存在正相关性(均P<0.001)。结论:孕妇脂血对其他生化检验项目均有影响,采用低温离心再处理有一定效果。存在脂血孕妇不良妊娠结局发生率更高。
Objective:To explore the influence of the lipemia of pregnant women on their biochemical test results,and to study the correlation between the lipemia of the pregnant women and their adverse pregnancy outcomes.Methods:A total of 102 pregnant women with hyperlipidemia who received antenatal examination and delivered in the hospital from December 2018 to December 2023 were collected in observation group retrospectively,and 102 normal pregnant women who received antenatal examination and delivered in the same hospital during the same period were selected in control group.The blood samples of the women in the observation group were handled by low temperature and high speed centrifugation,and the changes of the levels of the serum biochemical indexes,such as creatinine,alkaline phosphatase(ALP),creatine kinase isoenzyme(CK-MB),fasting blood glucose,aspartate aminotransferase(AST)and alanine aminotransferase(ALT)of the women in the observation group were compared between before and after handling the blood samples.The adverse maternal and infants outcomes were compared between the two groups.Receiver-ope rating characteristic(ROC)curve was used to analyze the assessment value of the hyperlipidemia of the women for their adverse pregnancy outcomes.Spearman correlation was used to analyze the correlation between the lipemia of the pregmant women and their adverse pregnancy outcomes.Results:The Cr,ALP,CK-MB,FBG,AST and ALT levels in the blood samples of the women in the observation group after handling the blood samples had decreased significantly,and the blood TC,TG,HDL-C and LDL-C levels of the women in the observation group were significantly higher than those of the women in the control group(all P<0.05).The adverse pregnancy outcomes rate(23.5%)of the women in the observation group was significantly higher than that(6.9%)of the women in the control group(P<0.05),but which had no significant different among the women diagnosed hyperlipidemia during the different gestational weeks in the observation group(P>0.05).The area under the ROC curve,the specificity and the sensitivity of the lipemia detection of the pregnant women with hyperlipidemia for their adverse pregnancy outcomes were 0.720,57.2%and90.3%,respectively.The blood lipid levels of the pregnant women with hyperlipidemia were positively correlated with the maternal and fetal adverse outcomes(all P<0.001).Conclusion:The lipemia of the pregnant women has certain influence on the other biochemical test items of the women,and the low temperature and the centrifugal reprocessing for the lipemia samples of the pregnant women has certain effect for decreasing the influence on the other biochemical test items of the women.The pregnant women with lipemia have the higher incidence of adverse pregnancy outcomes.
作者
肖纯荣
黎雪彬
李凯
李国伟
XIAO Chunrong;LI Xuebin;LI Kai;LI Guowei(Dechang County People's Hospital,Dechang,Sichuan Province,615500;Dujiangyan Traditional Chinese Medicine Hospital,Dujiangyan,Sichuan Province)
出处
《中国计划生育学杂志》
2024年第8期1959-1962,共4页
Chinese Journal of Family Planning
关键词
高脂血症孕妇
生化检验
血标本处理
不良妊娠结局
评估
相关性
Pregnant women with hyperlipemia
Biochemical test
Blood specimen handling
Adverse pregnancy outcomes
Assessment
Correlation
