摘要
胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,EPN)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对EPN的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对EPN的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对EPN影响及EPN的应用中胰岛素的干预应用提供思路及理论基础。
Insulin is a protein hormone with small molecular weight and secreted by insulin cells,regulating the metabolism of sugar,fat and protein by signaling pathways,and finally affecting organisms.The insulin signaling pathways present in insects and regulate the metabolism,growth and development,and lifespan,being highly homologous with those in vertebrates.Research on insulin signaling pathways in Drosophila melanogaster and Caenorhabditis elegans can be used as a probe in life science research to supply a test model for the study of human insulin-related diseases,which is of great significance to life science research,so the research on insulin in nematodes and insects is relatively in-depth.Entomopathogenic nematodes(EPNs)are important biocontrol factors,and their life cycle includes both the parasitism stage in host insects and the free life stage in nature.During the parasitism stage,the symbiotic bacteria carried by nematodes mainly act in the blood circulation system of host insects,resulting in the death of host insects.Therefore,there is a close relationship between EPNs and the blood system of host insects,thus the effect of insulin on EPNs must be studied on both nematodes and host insects.In order to scientifically and systematically investigate the effects of insulin on EPNs and conduct in-depth discussions,in this article we reviewed the physiological functions of insulin/insulin-like growth factors in insects and nematodes,so as to shed more lights on the theoretical basis for studying the effects of insulin on EPNs and the application of insulin,and insulin intervention in the application of EPNs.
作者
钱秀娟
刘长仲
杨亚贤
马丽娟
陈红
李茜童
Edwin E.LEWIS
QIAN Xiu-Juan;LIU Chang-Zhong;YANG Ya-Xian;MA Li-Juan;CHEN Hong;LI Xi-Tong;Edwin ELEWIS(Biocontrol Engineering Laboratory of Crop Diseases and Pests of Gansu Province,College of Plant Protection,Gansu Agricultural University,Lanzhou 730070,China;Department of Entomology,Plant Pathology and Nematology,College of Agricultural and Life Sciences,University of Idaho,Idaho,ID 83844-229,USA)
出处
《昆虫学报》
CAS
CSCD
北大核心
2024年第7期1006-1018,共13页
Acta Entomologica Sinica
基金
国家自然科学基金项目(31960559)
西藏自治区科技计划项目(XZ202301ZY0019N)。
关键词
胰岛素
昆虫
线虫
昆虫病原线虫
共生细菌
生理代谢
Insulin
insects
nematodes
entomopathogenic nematodes
symbiotic bacterium
physiological metabolism
