摘要
子痫前期多发生在妊娠20周之后,严重影响母胎健康,是全球孕产妇和围生儿病死率升高的主要原因。因此,探索能加快诊断子痫前期的生物标志物尤为重要。建立孕早中期子痫前期的诊断模型是减少孕产妇和婴儿病死率的重中之重。该文结合国内外近年来的研究成果对子痫前期发病机制及胎盘生长因子等血管生成标志物的临床应用方面进行了综述,旨在提高子痫前期早期诊断率,降低孕产妇并发症风险和围生儿病死率。
Pre-eclampsia,which mostly occurs often after 20 weeks of gestation,severely affects maternal and fetal health and is a major cause of increased maternal and perinatal mortality worldwide.Therefore,it is important to explore biomarkers that can expedite the diagnosis of preeclampsia.Establishing a diagnostic model for preeclampsia in early and mid-pregnancy is a top priority for reducing maternal and infant mortality.In this article,we review the pathogenesis of pre-eclampsia and the clinical application of angiogenic markers such as placental growth factor,with the aim of improving the early diagnosis of pre-eclampsia and reducing the risk of maternal complications and perinatal morbidity and mortality.
作者
周梦兰(综述)
欧明林(审校)
ZHOU Menglan;OU Minglin(Central Laboratory,the Second Affiliated Hospital of Guilin Medical University/Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders,Guilin,Guangxi 541000,China)
出处
《现代医药卫生》
2024年第16期2846-2849,2854,共5页
Journal of Modern Medicine & Health
基金
广西壮族自治区医疗卫生适宜技术开发与推广应用项目(S2022147)。
