摘要
目的探讨血清膜联蛋白A1(AnxA1)、基质金属蛋白酶-3(MMP-3)联合冠状动脉血管内超声钙化特征对非ST段抬高型急性冠脉综合征(NSTE-ACS)患者经皮冠状动脉介入治疗(PCI)术后冠状动脉再狭窄的预测价值。方法回顾性选取2019年7月至2022年5月鄂州市中心医院行PCI治疗的236例NSTE-ACS患者为研究对象,依据随访1年内冠状动脉再狭窄情况分为再狭窄组(n=24)和非狭窄组(n=212)。收集患者临床资料,对比患者血清AnxA1、MMP-3水平、血管内超声检查结果;采用Logistic多因素回归分析NSTE-ACS患者PCI术后冠状动脉再狭窄影响因素;受试者操作特征(ROC)曲线分析血清AnxA1、MMP-3水平联合钙化特征评分预测术后冠状动脉再狭窄的价值。结果再狭窄组血清AnxA1、MMP-3水平及钙化病变比例、浅表型钙化比例、钙化弧度、钙化长度、钙化特征评分分别为(2.40±0.61)μg/L、(56.49±12.31)μg/L、66.67%、70.83%、(162.18±28.43)°、(25.91±4.56)mm、(5.02±1.28)分,高于非狭窄组[(1.78±0.40)μg/L、(42.78±10.07)μg/L、22.64%、29.72%、(78.41±20.39)°、(13.72±3.68)mm、(3.47±1.02)分],差异均有统计学意义(P<0.05)。AnxA1、MMP-3、钙化特征评分是NSTE-ACS患者PCI术后冠状动脉再狭窄的独立危险因素(P<0.05)。AnxA1、MMP-3、钙化特征评分及3者联合预测NSTE-ACS患者PCI术后冠状动脉再狭窄的AUC分别为0.825、0.780、0.854、0.960。结论AnxA1、MMP-3、钙化特征评分是NSTE-ACS患者PCI术后冠状动脉再狭窄的独立危险因素,3者联合较单一指标对冠状动脉再狭窄的预测价值更高。
Objective To investigate the predictive value of serum annexin A1(AnxA1),matrix metalloproteinase 3(MMP-3)combined with intravascular ultrasound calcification characteristics of coronary arteries for coronary restenosis after percutaneous coronary intervention(PCI)in patients with non-ST segment elevation acute coronary sydrome(NSTE-ACS).Methods A total of 236 NSTE-ACS patients who underwent PCI treatment in Ezhou Central Hospital from July 2019 to May 2022 were retrospectively selected as the study subjects.They were separated into the restenosis group(n=24)and the non stenosis group(n=212)based on the condition of coronary restenosis within one year of follow-up.The clinical data of the patients were collected and the serum levels of AnxA1 and MMP-3 and the results of intravascular ultrasound examination were compared,the influencing factors of coronary restenosis in NSTE-ACS patients after PCI were analyzed by Logistic multiple regression,the predicting postoperative value of serum AnxA1,MMP-3 level combined with calcification feature score in coronary restenosis was analyzed by receiver operating characteristic(ROC)curve.Results The serum levels of AnxA1 and MMP-3,the proportion of calcified lesions,the proportion of superficial calcification,calcification arc,calcification length,and calcification characteristic score in the restenosis group were(2.40±0.61)μg/L,(56.49±12.31)μg/L,66.67%,70.83%,(162.18±28.43)°,(25.91±4.56)mm,(5.02±1.28)points,respectively,which were higher than those in the non stenosis group[(1.78±0.40)μg/L,(42.78±10.07)μg/L,22.64%,29.72%,(78.41±20.39)°,(13.72±3.68)mm,(3.47±1.02)points],the differences were statistically significant(P<0.05).AnxA1,MMP-3,and calcification characteristic score were independent risk factors for coronary restenosis after PCI in NSTE-ACS patients(P<0.05).The AUC of AnxA1,MMP-3,calcification feature score,and their combination in predicting coronary restenosis after PCI in NSTE-ACS patients was 0.825,0.780,0.854,and 0.960.Conclusion AnxA1,MMP-3,and calcification feature score are independent risk factors for coronary restenosis after PCI in NSTE-ACS patients,and the combination of the three indicators has higher predictive value for coronary restenosis than a single indicator.
作者
魏晓
湛疆
何定华
陈燕
蔡烈松
WEI Xiao;ZHAN Jiang;HE Ding-hua(Department of Cardiovascular,Ezhou Central Hospital,Ezhou Hubei 436000,China)
出处
《临床和实验医学杂志》
2024年第13期1373-1376,共4页
Journal of Clinical and Experimental Medicine
基金
湖北省卫生健康委科研项目(编号:WJ2021M266)
鄂州市科技计划项目(编号:EZ01-002-20200055)。
