摘要
目的:分析妊娠期糖尿病(GDM)患者血脂、凝血功能指标检测意义及对妊娠结局的预测价值。方法:选取2020年5月至2023年5月本院收治的76例GDM患者为GDM组,同期选取50例正常妊娠孕妇为对照组。入组者均随访至妊娠后,以不同妊娠结局将GDM组分为两个亚组:正常分娩组与不良妊娠组,分别为58例、18例。回顾性分析入组者临床资料,对比对照组与GDM组、正常分娩组与不良妊娠组各项检查指标,以Pearson法对凝血功能、血脂指标与GDM患者胰岛素抵抗程度的相关性进行分析,并分析血脂联合凝血功能指标对GDM不良妊娠结局的预测价值。结果:GDM组TG、TC、LDL-C、D-D、FIB及胰岛素抵抗指数较对照组更高,APTT、PT、胰岛素分泌指数较对照组更低(P<0.05);不良妊娠组TG、LDL-C、D-D、FIB较正常分娩组更高,APTT、PT较正常分娩组更低(P<0.05);Pearson相关性分析显示,GDM患者TG、LDL-C、FIB、D-D均与胰岛素抵抗指数呈正相关(P<0.05),与胰岛素分泌指数呈负相关(P<0.05);血脂联合凝血功能指标对GDM不良妊娠结局预测价值的敏感度为92.65%,特异性为87.76%,曲线下面积(AUC)为0.910。结论:血脂、凝血功能指标异常变化与GDM发生有着相关性,联合检测对妊娠结局的预测价值较高,可指导临床诊治。
Objective:To analyze the significance of blood lipid and coagulation function in patients with gestational diabetes mellitus(GDM)and its predictive value for pregnancy outcome.Methods:76 cases of GDM patients admitted to our hospital from May 2020 to May 2023 were selected as the GDM group,and 50 cases of normal pregnant women were selected as the control group.All the participants were followed up to pregnancy,and the GDM group was divided into two subgroups according to different pregnancy outcomes:normal delivery group and adverse pregnancy Group,58 cases,18 cases,respectively.The clinical data of the participants were retrospectively analyzed,the examination indexes of normal delivery group and adverse pregnancy Group,and the correlation between blood coagulation function,blood lipid indexes and insulin resistance degree of GDM patients were analyzed by Pearson method,the predictive value of blood lipid combined with coagulation function index on GDM adverse pregnancy outcome was analyzed.Results:TG,TC,LDL-C,D-D,FIB and insulin resistance index in GDM group were higher than those in control group,and APTT,PT and insulin secretion index were lower than those in control group(P<0.05);TG,LDL-C,D-D and FIB in adverse pregnancy Group were higher than those in normal delivery group,APTT and PT were lower than those in normal delivery group(P<0.05).Pearson correlation analysis showed that TG,LDL-C,both FIB and D-D were positively correlated with insulin resistance Index(P<0.05)and negatively correlated with insulin secretion Index(P<0.05);the sensitivity,specificity and area under the curve(ACC)of blood lipid combined with coagulation function index to predict GDM adverse pregnancy outcome were 92.65%,87.76%and 0.910%respectively.Conclusion:The abnormal changes of blood lipid and coagulation function are related to the occurrence of GDM,and the combined detection has a high predictive value for pregnancy outcome,which can guide clinical diagnosis and treatment.
作者
刘树妍
Liu Shuyan(Department of Obstetrics,Maternal and Child Health and Family Planning Service Center,Donggang District,Rizhao Shandong,276800,China)
出处
《中外女性健康研究》
2024年第8期22-25,共4页
Women＇s Health Research
关键词
妊娠期糖尿病
血脂
高密度脂蛋白胆固醇
凝血功能
妊娠结局
预测价值
Gestational diabetes mellitus
Blood lipid
High density lipoprotein cholesterol
Coagulation function
Pregnancy outcome
Predictive value
