摘要
目的:研究加味黄连温胆汤治疗痰瘀互结型代谢综合征(MS)的临床疗效及其对认知功能的影响。方法:选取2022年6月—2023年3月就诊于黑龙江中医药大学附属第一医院心血管一科门诊的MS合并轻度认知功能障碍(MCI)病人70例,运用随机数字表法将其分为两组,对照组采用常规西药治疗,观察组在此基础上联合加味黄连温胆汤。治疗4周后,比较两组病人治疗前后中医证候积分、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FPG)、血清胰岛素(FINS)及胰岛素抵抗指数(HOMA-IR)、蒙特利尔认知评估量表(MoCA)评分及不良反应发生情况。结果:治疗后两组病人中医证候积分、BMI、SBP、DBP、TG、TC、LDL、FPG、FINS及HOMA-IR水平均较治疗前降低,且观察组明显优于对照组,差异均有统计学意义(P<0.05)。治疗后两组MoCA评分及HDL水平均提高,且观察组优于对照组,差异均有统计学意义(P<0.05)。两组病人治疗中均未发生不良反应。结论:加味黄连温胆汤联合常规西药治疗可有效改善MS合并MCI病人的临床症状,调节糖脂代谢,改善认知功能,且无不良反应。
Objective:To investigate the clinical effect of Huanglian Wendan decoction on metabolic syndrome(MS)with phlegm stasis and its influence on cognitive function.Methods:A total of 70 MS patients with mild cognitive impairment(MCI)were selected.The patients were divided into two groups using the random number table method.The patients in control group were treated with conventional western medicine,and the patients in observation group was treated with modified Huanglian Wendan decoction on this basis,for 4 weeks treatment.TCM syndrome score,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),triglyceride(TG),cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),fasting blood glucose(FPG),serum insulin(FINS)and insulin resistance index(HOMA-IR),Montreal Cognitive Assessment Scale(MoCA)score,and the occurrence of adverse reactions were compared between the two groups before and after treatment.Results:After treatment,TCM syndrome score,BMI,SBP,DBP,TG,TC,HDL,FPG,FINS,and HOMA-IR levels in the 2 groups decreased,and the index of observation group were significantly better than those in control group,the differences were statistically significant(P<0.05).After treatment,the MoCA score and LDL level of two groups increased,and those in observation group were better than those in control group,the differences were statistically significant(P<0.05).No adverse reactions occurred in the two groups.Conclusion:Modified Huanglian Wendan Decoction combined with conventional Western medicine can effectively improve the clinical symptoms of MS patients with MCI,regulate glucose and lipid metabolism,and improve cognitive function without any adverse reactions.
作者
张萍萍
韩宇博
姚春丽
邹国良
隋艳波
刘莉
ZHANG Pingping;HAN Yubo;YAO Chunli;ZOU Guoliang;SUI Yanbo;LIU Li(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《中西医结合心脑血管病杂志》
2024年第16期2923-2927,共5页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家自然科学基金面上项目(No.82074346,82205060,82274473)
黑龙江中医药大学“双一流”中西医结合学科发展助力基金项目(No.HLJSYL21011)
黑龙江省中医药管理局科研项目(No.ZHY2022-148)。
关键词
代谢综合征
轻度认知功能障碍
加味黄连温胆汤
metabolic syndrome
mild cognitive impairment
Modified Huanglian Wendan Decoction
