摘要
目的:观察半夏白术天麻汤合通窍活血汤联合治疗痰瘀互结型高血压(HTN)颈动脉斑块疗效及对中医证候积分和血脂代谢的影响。方法:选取我院2021年1月~2022年6月收治的HTN伴颈动脉斑块患者62例。按照随机数字表法将患者分为治疗组(n=31)与对照组(n=31),两组均予以基础治疗,对照组以西药服用治疗,治疗组以西药+半夏白术天麻汤合通窍活血汤治疗,比较治疗后临床疗效,治疗前后中医症候积分、血压监测、血脂水平、超声检查[颈动脉内膜-中层厚度(IMT)、Grouse积分]、实验室指标[同型半胱氨酸(Hcy)、C反应蛋白(CRP)]。结果:治疗4个疗程后,治疗组临床疗效为28/31(90.32%)较对照组22/31(70.97%)更高(P<0.05);两组中医证候积分、收缩压(SBP)、舒张压(DBP)、低密度脂蛋白(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、IMT、Crouse积分、血清Hcy、CRP水平均降低(P<0.05),且治疗组降幅高于对照组(P<0.05);两组高密度脂蛋白(HDL-C)均升高(P<0.05),且治疗组升幅高于对照组(P<0.05)。结论:半夏白术天麻汤合通窍活血汤联合治疗痰瘀互结型HTN伴颈动脉斑块可通过调节血脂代谢及血压水平,有效促进斑块消除,进而改善患者临床症状。
To explore the efficacy of Banxia Baizhu Tianma decoction combined with Tongqiao Huoxue decoction in the treatment of intermingled phlegm and blood stasis type of hypertension(HTN)with carotid plaques and the influence on TCM syndromes scores and blood lipid metabolism.Methods:62patients with HTN and carotid plaques in our hospital from January 2021to June 2022were selected.According to the random number table method,the patients were divided into treatment group(n=31)and control group(n=31).Both groups were given basic treatment,and the control group was treated with western medicine while the treatment group was given western medicine+Banxia Baizhu Tianma decoction with Tongqiao Huoxue decoction.The clinical efficacy after treatment and TCM symptoms scores,blood pressure monitoring,blood lipids levels,ultrasound examination[carotid intima-media thickness(IMT),Grouse score]and laboratory indicators[homocysteine(Hcy),C-reactive protein(CRP)]before and after treatment were compared.Results:After 4courses of treatment,the clinical efficacy in treatment group was 28/30(90.32%),which was higher than 22/31(70.97%)in control group(P<0.05).The TCM syndromes scores,systolic blood pressure(SBP),diastolic blood pressure(DBP),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG),IMT,Crouse score,serum Hcy and CRP were decreased in the two groups(P<0.05),and the decreases were higher in treatment group(P<0.05).The high-density lipoprotein cholesterol(HDL-C)in both groups was increased(P<0.05),and the increase was higher in treatment group than that in control group(P<0.05).Conclusion:Banxia Baizhu Tianma decoction combined with Tongqiao Huoxue decoction can effectively promote the plaque elimination by regulating blood lipid metabolism and blood pressure in treating intermingled phlegm and blood stasis type of HTN with carotid plaques,thereby improving the clinical symptoms of patients.
作者
王静
唐晓敏
程超超
姚舒雅
WANG Jing;TANG Xiaomin;CHENG Chaochao(Department of Traditional Chinese Medicine,The First People's Hospital of Hefei,Hefei Anhui 230061,China)
出处
《四川中医》
2024年第7期102-106,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
合肥市2021年中医药研究课题项目立项项目(编号:合卫中医秘[2020]号)。
关键词
半夏白术天麻汤
通窍活血汤
痰瘀互结型
高血压
颈动脉斑块
中医证候积分
血脂代谢
Banxia Baizhu Tianma decoction
Tongqiao Huoxue decoction
Intermingled phlegm and blood stasis type
Hypertension
Carotid plaques
TCM Syndrome Points
Lipid metabolism
