摘要
目的:研究清热利咽汤对行放化疗鼻咽癌患者口腔黏膜炎发生率的影响。方法:本文选取2018年5月~2023年6月在我院放射科治疗的鼻咽癌患者110例,按随机数字法将患者分为对照组、观察组,各55例。对照组放化疗后给予还原型谷胱甘肽钠;观察组在对照组的基础上给予清热利咽汤。检测CD4^(+)/CD8^(+)、CD19^(+)/CD69^(+)、骨型碱性磷酸酶(B-ALP)、血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP-2)、生命质量表-头颈癌(QLICP-HN)、症状积分。统计治疗有效率、口腔黏膜炎发生率。结果:观察组治疗后CD4^(+)/CD8^(+)、CD19^(+)/CD69^(+)水平高于对照组治疗后,B-ALP水平低于对照组治疗后(P<0.05)。观察组治疗后VEGF、MMP-2水平及QLICP-HN评分低于对照组治疗后(P<0.05)。观察组治疗后溃疡、咽痛灼热、脓涕腥臭及咽干口渴积分低于对照组治疗后(P<0.05)。观察组治疗后总有效率高于对照组(P<0.05)。两组患者治疗后,观察组口腔黏膜炎发生率低于对照组(P<0.05)。结论:清热利咽汤对行放化疗鼻咽癌患者的治疗效果显著,可降低口腔黏膜炎发生率,减轻患者炎症反应,提高生活质量,有利于患者恢复。
Objective:To investigate the effect of Qingre Liyan Decoction on the rate of oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy and chemotherapy.Methods:In this paper,110patients with nasopharyngeal cancer treated in the radiology department of our hospital from May 2018to June 2023were selected,and the patients were divided into control group and observation group according to random method,with 55cases each.The control group received reduced glutathione sodium after radiotherapy;the observation group gave Qingreili soup on the basis of the control group.CD4^(+)/CD8^(+),CD19^(+)/CD69^(+),bone-type alkaline phosphatase(B-ALP),vascular endothelial growth factor(VE GF),matrix metalloproteinase(MMP-2),quality of life table-head and neck cancer(QLICP-HN),symptom integration were tested.Statistical treatment efficiency and incidence of oral mucositis.Results:CD4^(+)/CD8^(+)and CD19^(+)/CD69^(+)levels were higher than those in the control group,and B-ALP levels were lower than those in the control group(P<0.05).VE GF,MMP-2levels and QLIICPHN scores in the observation group were lower than those in the control group(P<0.05).The score of ulcer,sore throat,pus and dry throat thirst were lower than that of the control group(P<0.05).The total response rate in the observation group was higher after treatment than that in the control group(P<0.05).After treatment of patients in both groups,the incidence of oral mucositis in the observation group was lower than that in the control group(P<0.05).Conclusion:Qingrelipharyngeal soup has a significant effect on the treatment of nasopharyngeal cancer patients,which can reduce the incidence of oral mucositis,reduce the inflammation of patients,improve the quality of life,and is conducive to the recovery of patients.
作者
蔡琰
张霁雯
龚齐
CAI Yan;ZHANG Jiwen;GONG Qi(Department of Otolaryngology,Luodian Hospital Baoshan District,Shanghai 201908,China;Department of Gastroenterology,Luodian Hospital,Baoshan District,Shanghai 201908,China;Department of Otolaryngology,Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine(Baoshan Branch,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine),Shanghai 201900,China)
出处
《四川中医》
2024年第7期175-178,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
清热利咽汤
放化疗
鼻咽癌
口腔黏膜炎发生率
Qingre Liyan Decoction
Radiotherapy
Nasopharyngeal carcinoma
Oral mucositis rate
