摘要
The impact of alternate-day fasting(ADF)on atherosclerosis remains poorly understood,particularly in high-risk populations.In a recent paper published in Life Metabolism,Deng et al.revealed that ADF exacerbated both early and advanced atherosclerotic lesion development in Apoe^(-/-)mice through suppression of hepatic activating transcription factor 3(ATF3)and consequent dysregulation of cholesterol metabolism.
基金
supported by the Canadian Institute of Health Research(CIHR)Fellowship.H.K.S.was supported by the Canadian Institute of Health Research(CIHR,PJT-190016)
the Natural Sciences and Engineering Research Council(NSERC,RGPIN-2016-06610)of Canada
the Sun Life Financial New Investigator Award of Banting&Best Diabetes Centre(BBDC)of University of Toronto.
