摘要
为探索化妆品原料水解玉米淀粉的舒缓功效,通过人永生化角质形成细胞和斑马鱼模型进行功效测试。水解玉米淀粉在质量浓度为0.05、0.1、0.2 g/L时使细胞中辣椒素诱导的瞬时受体电位香草醛亚家族1(TRPV1)表达均呈下调趋势,降钙素基因相关肽(CGRP)的表达均呈上调趋势;在质量浓度为1.2 g/L时能降低十二烷基硫酸钠诱导的斑马鱼翻滚圈数,在质量浓度为30.0、6.0、1.2 g/L时降低斑马鱼中性粒细胞的聚集。因此,水解玉米淀粉具有舒缓功效。
In order to study the soothing effect of hydrolyzed corn starch as a cosmetic raw material,the efficacy was tested by human immortalized keratinocytes and zebrafish models.Hydrolyzed corn starch down-regulated the expression of transient receptor potential vanilloid subfamily 1(TRPV1)induced by capsaicin and up-regulated the gene expression of calcitonin gene related peptide(CGRP)at the concentrations of 0.05,0.1,0.2 g/L.Hydrolyzed corn starch at the concentration of 1.2 g/L could reduce the number of zebrafish tumbling induced by sodium dodecyl sulfate.At concentrations of 30.0,6.0,1.2 g/L,it could also reduce the aggregation of neutrophils in zebrafish.These results indicated that hydrolyzed corn starch had a soothing efficacy.
作者
王艳
李娟
范正松
WANG Yan;LI Juan;FAN Zhengsong(Jiangxi China Cosmetics Inspection and Testing Center Co.,Ltd.,Nanchang 330000,Jiangxi,China;Jiangxi Chufu Cosmetics Co.,Ltd.,Nanchang 330000,Jiangxi,China)
出处
《香料香精化妆品》
CAS
2024年第4期120-124,共5页
Flavour Fragrance Cosmetics
关键词
化妆品原料
水解玉米淀粉
敏感性皮肤
舒缓功效
cosmetic raw material
hydrolyzed corn starch
sensitive skin
soothing efficacy
