摘要
目的:探讨安顺地区尿路感染500例细菌谱监测及耐药性,为安顺地区基层医院临床合理用药提供依据。方法:选取就诊于安顺地区医疗机构500例泌尿系统感染患者,统计分析地区尿路感染患者感染病原体及对抗生素的耐药率,比较不同性别、年龄段患者细菌谱及主要病原菌对不同抗生素的耐药率。结果:安顺地区尿路感染患者分离病原体感染革兰氏阴性菌336株,感染革兰氏阳性菌105株,感染真菌59株,尿路感染患者细菌分布中大肠埃希菌感染率最高27.20%,其次是屎肠球菌13.80%、肺炎克雷伯菌13.60%、念珠菌11.80%;不同性别、年龄段尿路感染患者分离病原体分布差异具有统计学意义(P<0.05),其中大肠埃希菌女性患者、≥60岁患者感染率显著高于男性患者、<60岁患者;男性患者大肠埃希菌对美罗培南、氨苄西林/舒巴、左旋氧氟沙星、氨曲南、头孢吡肟、头孢他啶、亚胺培南耐药率显著高于女性(P<0.05),不同年龄段尿路感染主要病原体的耐药率差异无统计学意义(P>0.05)。结论:尿路感染患者病原菌分布与性别、年龄密切相关,而耐药率仅与性别相关;临床治疗尿路感染时男性患者应更多覆盖革兰氏阳性球菌和念珠菌,女性患者应考虑更多是革兰氏阴性杆菌。
Objective:To investigate the bacterial spectrum monitoring and drug resistance of 500 cases of urinary tract infection in the Anshun area,and to provide evidence for clinical rational drug use in basic hospitals in the Anshun area.Methods:A total of 500 patients with urinary system infection were selected,and the pathogen infection and antibiotic resistance rates of patients with urinary tract infection in the region were statistically analyzed,and the bacterial spectrum of patients with different genders and ages was compared.The resistance rates of main pathogens to different antibiotics in different sex and age groups were analyzed.Result:In the Anshun area,the isolated pathogens infected G-bacteria rate of 336 strains,G+ bacteria rate of 105 strains,and fungal infection rate of 59 strains.In the bacterial distribution of urinary tract infection patients,the infection rate of Escherichia coli was the highest 27.20%,followed by Enterococcus faecium 13.80%,Klebsiella pneumoniae 13.60%,11.80%,There was statistical significance in the distribution of isolated pathogens in patients with urinary tract infection of different genders and ages(P<0.05).The distribution infection rate of Escherichia coli in female and ≥60 years old patients was significantly higher than that in male and <60 years old patients.The resistance rate of E.coli to meropenem,ampicillin/sulba,levofloxacin,amtraxam,cefepime,ceftazidime,and imipenem in male patients was significantly higher than that in female patients(P<0.05),but there was no significant difference in the resistance rate of major pathogens of urinary tract infection among different age groups(P>0.05).Conclusion:The distribution of pathogenic bacteria in patients with urinary tract infections is closely related to gender and age,while the drug resistance rate is only related to gender.In the clinical treatment of urinary tract infections,more G+ bacteria and candida should be covered in the treatment of male patients,and women should think more about killing G-bacilli.
作者
杨奇志
肖海涛
赵震东
杨超
王威威
YANG Qizhi;XIAO Haitao;ZHAO Zhendong;YANG Chao;WANG Weiwei(Department of Urology,the 302 Hospital of china Guizhou Aviation Group Anshun)
出处
《长治医学院学报》
2024年第4期268-271,共4页
Journal of Changzhi Medical College
基金
安顺市科技计划项目(安市科社[2022]23号)。
关键词
尿路感染
细菌谱
耐药率
抗生素
urinary tract infection
bacterial spectrum
drug resistance rate
antibiotics
