摘要
目的:探讨重组人干扰素α-2b凝胶联合微波治疗慢性宫颈炎的效果。方法:选取榆林市子洲县人民医院2020年6月—2023年7月收治的慢性宫颈炎患者98例为研究对象,随机分为对照组和试验组,各49例。对照组给予微波治疗,试验组在对照组基础上采用重组人干扰素α-2b凝胶治疗。比较两组治疗总有效率、免疫功能、自然杀伤T细胞、血管内皮生长因子水平及Nugent量表评分。结果:试验组治疗总有效率高于对照组,差异有统计学意义(P=0.014);治疗后,两组CD3+、CD4+水平高于治疗前,CD8+水平低于治疗前,试验组CD3+、CD4+水平高于对照组,CD8+水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组自然杀伤T细胞、血管内皮生长因子水平高于治疗前,试验组高于对照组,差异有统计学意义(P<0.05);治疗后,两组下腹部疼痛、外阴瘙痒及白带异常评分低于治疗前,试验组低于对照组,差异有统计学意义(P<0.05)。结论:重组人干扰素α-2b凝胶联合微波治疗慢性宫颈炎的效果较好,可提高免疫功能,改善临床症状。
Objective:To investigate the effect of recombinant human interferonα-2b gel combined with microwave in the treatment of chronic cervicitis.Methods:Ninety-eight patients with chronic cervicitis treated in Yulin Zizhou County People's Hospital from June 2020 to July 2023 were selected as the study objects,and were randomly divided into control group and experimental group,with forty-nine cases in each group.The control group was treated with microwave,and the experimental group was treated with recombinant human interferonα-2b gel.The total effective rate,immune function,levels of natural killer T cells,vascular endothelial growth factor and Nugent scale were compared between the two groups.Results:The total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P=0.014);after treatment,the levels of CD3+and CD4+in two groups were higher than before treatment,and the levels of CD8+were lower than before treatment,and the levels of CD3+and CD4+in experimental group were higher than those in control group,and the levels of CD8+were lower than those in control group,the difference was statistically significant(P<0.05);after treatment,the levels of natural killer T cells and vascular endothelial growth factor in two groups were higher than before treatment,and those in experimental group were higher than those in control group,the difference was statistically significant(P<0.05);after treatment,the scores of lower abdominal pain,vulvar pruritus and abnormal leucorrhea in the two groups were lower than before treatment,and the scores in the experimental group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion:Recombinant human interferonα-2b gel combined with microwave has a good effect in the treatment of chronic cervicitis,which can improve immune function and clinical symptoms.
作者
王改梅
朱芳
Wang Gaimei;Zhu Fang(Yulin Zizhou County People's Hospital,Yulin 718400,Shaanxi Province,China)
出处
《中外医药研究》
2024年第22期36-38,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
