摘要
乳腺癌是全球高发恶性肿瘤之一,骨转移是乳腺癌全周期的常见并发症,易形成“肿瘤-骨微环境”的恶性循环,从而导致骨相关事件的发生,如骨痛、病理性骨折和高钙血症等。研究发现雷公藤有效成分具有抗乳腺癌和调控骨微环境的作用,包括抑制肿瘤细胞增殖和迁移、抑制肿瘤血管生成、诱导肿瘤细胞自噬、调控成骨细胞的骨形成、抑制破骨细胞的骨吸收、促进骨髓间充质干细胞向成骨细胞分化以及调控免疫微环境等,有助于抑制乳腺癌及其骨转移。该文系统性地综述了雷公藤防治乳腺癌及其骨转移的药理研究进展,并分析了当前研究的局限性及应用前景。
Breast cancer is one of the most prevalent malignant tumors.Bone metastasis is a common complication during the entire course of breast cancer.The vicious cycle of“tumor-bone microenvironment”was easily formed,which led to the occurrence of bone-related events such as bone pain,pathological fractures,and hypercalcemia,etc.Studies have found that active ingredients of Tripterygium wilfordii exhibit the effect of anti-breast cancer and regulation of bone microenvironment,including inhibition of tumor cell proliferation and migration,inhibition of tumor angiogenesis,induction of autophagy in tumor cells,regulation of bone formation in osteoblast cell,inhibition of bone resorption in osteoclast cell,promoting the differentiation of bone marrow mesenchymal stem cells into osteoblasts,and regulation of immune microenvironment,which may be helpful to inhibit breast cancer and bone metastasis.This article systematically reviewed the research progress on pharmacological effects of Tripterygium wilfordii in preventing breast cancer and bone metastasis,analyzed the limitations and application prospects of the current research.
作者
张静
李静蔚
陈子超
李保宏
邹艺璇
刘辉
张秀云
张振
ZHANG Jing;LI Jingwei;CHEN Zichao;LI Baohong;ZOU Yixuan;LIU Hui;ZHANG Xiuyun;ZHANG Zhen(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355 Shandong,China;Innovation Research Institute of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355 Shandong,China;The First Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan 250035 Shandong,China;Experimental Center,Shandong University of Traditional Chinese Medicine,Jinan 250355 Shandong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2024年第8期1272-1280,共9页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(21775061)
山东省高等学校青创人才引育计划(2021505031)
济南市“新高校20条”资助项目(202228085)。
关键词
雷公藤
活性成分
乳腺癌
骨转移
恶性循环
骨微环境
Tripterygium wilfordii
active ingredients
breast cancer
bone metastasis
vicious circle
bone microenvironment
