摘要
癌症的主动免疫治疗旨在通过诱导有效的细胞免疫和体液免疫治疗疾病。近年针对病毒样颗粒(VLPs)疫苗的研究取得了巨大发展,极大降低了一些传染病的发病率和死亡率。VLPs是由一种或多种结构蛋白自组装而成的纳米颗粒,具有高度有序的重复序列及良好的免疫原性,可诱导较强的细胞免疫和体液免疫应答。VLPs可以克服肿瘤微环境的免疫抑制状态,打破自我耐受,引发强烈的细胞毒性T淋巴细胞活性,对病毒清除和肿瘤细胞破坏至关重要。本文主要综述目前基于VLPs的癌症疫苗研究进展,以及VLPs作为疫苗载体在癌症疫苗开发中的潜在缺陷。
Active immunotherapy for cancer aims to treat disease by inducing effective cellular immunity and humoral immunity.Research on virus-like particles(VLPs)vaccines has made tremendous progress in recent years,dramatically reducing morbidity and mortality from some infectious diseases.VLPs are nanoparticles self-assembled from one or more structural proteins,with highly ordered repeat sequences and good immunogenicity,which can induce strong cellular immune and humoral immune responses.VLPs can overcome immunosuppressive state of tumor microenvironment,break self-tolerance,and trigger strong cytotoxic T lymphocyte activity,which is critical for both viral clearance and destruction of cancer cells.This article mainly reviews current research progress of VLPs-based cancer vaccines and potential defects of VLPs as vaccine carriers in development of cancer vaccines.
作者
舒星富
陈遥
马小梅
苏津贤
柏家林
张海霞
马忠仁
SHU Xingfu;CHEN Yao;MA Xiaomei;SU Jinxian;BAI Jialin;ZHANG Haixia;MA Zhongren(Biomedical Research Center,Key Laboratory of Bioengineering and Biotechnology of the State Ethnic Affairs Commission,Northwest Minzu University,Lanzhou 730030,China;Life Science and Engineering College,Northwest Minzu University,Lanzhou 730030,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2024年第8期1590-1594,共5页
Chinese Journal of Immunology
基金
国家自然科学基金(31860696)
2020年度甘肃省教育厅高等学校创新基金项目(2020B-066)
西北民族大学中央高校基本科研业务费资金项目(31920190085)。
关键词
肿瘤
疫苗
病毒样颗粒
Tumor
Vaccines
Virus-like particles
