摘要
目的探讨重组人干扰素α2b与阿昔洛韦联合治疗疱疹性咽峡炎(HA)患儿的临床效果及其应用价值。方法选取2022年1月至2022年12月收治的108例HA患儿,根据治疗方法不同分为单药治疗组和联合治疗组,每组54例。单药治疗组予以阿昔洛韦治疗,联合治疗组予以重组人干扰素α2b联合阿昔洛韦治疗。比较两组的治疗总有效率、症状消失时间、心肌损伤指标、炎性因子和免疫功能及不良反应。结果联合治疗组治疗总有效率96.30%,高于单药治疗组的85.19%,临床症状消失时间短于单药治疗组,差异有统计学意义(P<0.05)。治疗7 d后,联合治疗组心肌损伤指标、炎性因子水平及CD3+低于单药治疗组,免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)及CD4+高于单药治疗组(P<0.05)。联合治疗组不良反应发生率为9.26%,与单药治疗组5.56%比较,差异无统计学意义(P>0.05)。结论重组人干扰素α2b与阿昔洛韦联合治疗HA患儿有助于抑制炎性反应,恢复心肌功能,增强机体免疫功能,提高治疗效果。
Objective To investigate the clinical efficacy of the combination of recombinant human interferonα2b and acyclovir in the children with herpetic angina(HA)and its application value.Methods 108 children with HA were retrospectively selected from January 2022 to December 2022 and divided into monotherapy group(n=54)and combination group(n=54)according to different treatment.Methods The patients in the monotherapy group were treated with acyclovir,and the patients in the combination group were treated with recombinant human interferonα2b combined with acyclovir.The total effective rate,clinical symptoms disappearance time,adverse reactions,myocardial injury,inflammatory factor and immune function levels before and after treatment were compared between the monotherapy group and combination group.Results The total effective rate in the combination group was 96.30%,which was higher than 85.19%in the monotherapy group,showing a statistically significant difference(P<0.05).After trentment for 7 d,the serum myocardial injury index,inflammatory factor level and CD3~+in the combination group were lower than those in the monotherapy group,while immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)and CD4~+in the combination group were higher than those in the monotherapy group(P<0.05).The incidence of adverse reactions in the combination group was 9.26%,which was no statistically significant compared with 5.56%in the monotherapy group(P>0.05).Conclusion Recombinant human interferonα2b combined with acyclovir is effective therapy in children with HA,which accelerates the process of rehabilitation,alleviates effectively the clinical symptoms,improves the myocardial injury,inhibits the inflammatory response,and enhances the immune function.
作者
靳宁超
胡青青
杨双杰
JIN Ningchao;HU Qingqing;YANG Shuangjie(Department of Pediatrics,the First People′s Hospital of Xiangfu District,Kaifeng 475100,China;Department of Pediatrics,Kaifeng Children′s Hospital,Kaifeng 475100,China)
出处
《华夏医学》
CAS
2024年第4期179-184,共6页
Acta Medicinae Sinica
基金
河南省医学科技攻关联合共建项目(LHGJ20223470)。
