摘要
目的观察临床对精神分裂症患者开展小剂量阿立哌唑联合奥氮平治疗的效果,并分析其对患者认知功能的影响。方法选取精神分裂症患者60例作为研究主体,根据就诊病历号奇数偶数分为对照组(30例)和观察组(30例)。对照组开展小剂量阿立哌唑进行治疗,观察组在对照组基础上开展奥氮平联合治疗。比较两组临床疗效,治疗前后临床症状、精神状态、睡眠质量、认知功能。结果观察组治疗总有效率86.67%与对照组的63.33%相比显著更高(P<0.05)。两组治疗后思维紊乱、情感混乱、感知异常评分与同组治疗前相比显著更低,且观察组治疗后思维紊乱、情感混乱、感知异常评分分别为(2.10±0.67)、(2.25±0.54)、(2.52±0.60)分,与对照组的(3.46±0.72)、(3.63±0.81)、(3.89±0.78)分相比显著更低(P<0.05)。两组治疗后精神性焦虑、情感交流障碍、焦虑性运动评分与同组治疗前相比显著更低,且观察组治疗后精神性焦虑、情感交流障碍、焦虑性运动评分分别为(2.85±0.61)、(2.67±0.52)、(2.37±0.32)分,与对照组的(3.96±0.70)、(3.87±0.65)、(3.59±0.40)分相比显著更低(P<0.05)。两组治疗后入睡困难、睡眠满意度、睡眠问题评分与同组治疗前相比显著更低,且观察组治疗后入睡困难、睡眠满意度、睡眠问题评分分别为(1.86±0.17)、(1.40±0.12)、(1.42±0.23)分,与对照组的(2.62±0.20)、(2.72±0.15)、(2.68±0.30)分相比显著更低(P<0.05)。两组治疗后注意力、记忆、口头表达流畅性、语言视觉、空间认知能力评分与同组治疗前相比显著更高,且观察组治疗后注意力、记忆、口头表达流畅性、语言视觉、空间认知能力评分分别为(69.24±3.61)、(71.10±4.91)、(72.19±3.81)、(69.27±5.46)、(70.28±5.95)分,与对照组的(62.80±4.73)、(63.72±3.68)、(65.37±5.02)、(62.00±4.76)、(63.77±3.83)分相比显著更高(P<0.05)。结论精神分裂症患者临床开展小剂量阿立哌唑联合奥氮平治疗的效果良好,能够改善患者临床症状、精神状态,提高睡眠质量及认知功能,可进一步推广。
Objective To observe the effect of low-dose aripiprazole combined with olanzapine in the treatment of schizophrenia patients,and analyze its influence on cognitive function of patients.Methods 60 patients with schizophrenia were selected as subjects of the study and divided into a control group(30 cases)and an observation group(30 cases)according to the odd-even number of medical record number.The control group received low-dose aripiprazole treatment,and the observation group received olanzapine treatment based on the control group.The clinical efficacy,clinical symptoms,mental state,sleep quality and cognitive function before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 86.67%,which was significantly higher than 63.33%of the control group(P<0.05).After treatment,the scores of thinking disorder,emotional disorder and abnormal perception in the two groups were significantly lower than those before treatment;the scores of thinking disorder,emotional disorder and abnormal perception in the observation group were(2.10±0.67),(2.25±0.54)and(2.52±0.60)points,which were significantly lower than(3.46±0.72),(3.63±0.81)and(3.89±0.78)points in the control group(P<0.05).After treatment,the scores of mental anxiety,affective communication disorder and anxious motor in the two groups were significantly lower than those before treatment;the scores of mental anxiety,affective communication disorder and anxious motor in the observation group were(2.85±0.61),(2.67±0.52)and(2.37±0.32)points,which were significantly lower than(3.96±0.70),(3.87±0.65)and(3.59±0.40)points in the control group(P<0.05).After treatment,the scores of sleep difficulty,sleep satisfaction and sleep problems in the two groups were significantly lower than those before treatment;the scores of sleep difficulty,sleep satisfaction and sleep problem in the observation group were(1.86±0.17),(1.40±0.12)and(1.42±0.23)points,which were significantly lower than(2.62±0.20),(2.72±0.15)and(2.68±0.30)points in the control group(P<0.05).After treatment,the scores of attention,memory,verbal fluency,verbal vision and spatial cognition in the two groups were significantly higher than those before treatment;the scores of attention,memory,verbal fluency,verbal vision and spatial cognition in the observation group were(69.24±3.61),(71.10±4.91),(72.19±3.81),(69.27±5.46)and(70.28±5.95)points,which were significantly higher than(62.80±4.73),(63.72±3.68),(65.37±5.02),(62.00±4.76)and(63.77±3.83)points in the control group(P<0.05).Conclusion The effect of low-dose aripiprazole combined with olanzapine in the treatment of schizophrenia is good,which can improve the clinical symptoms,mental state,sleep quality and cognitive function of patients,and can be further promoted.
作者
张丽
孙梦梦
李程程
ZHANG Li;SUN Meng-meng;LI Cheng-cheng(Tai'an Mental Hospital,Tai'an 271000,China)
出处
《中国现代药物应用》
2024年第16期118-121,共4页
Chinese Journal of Modern Drug Application
关键词
小剂量阿立哌唑
奥氮平
精神分裂症
临床症状
认知功能
Low-dose aripiprazole
Olanzapine
Schizophrenia
Clinical efficacy
Cognitive function
