摘要
目的探讨血浆同型半胱氨酸(Hcy)水平与主动脉疾病风险的相关性。方法选取自2018年1月至2023年8月期间中国医科大学附属第一医院收治的220例主动脉疾病患者为研究对象。按主动脉疾病类型分为A组(n=75,急性主动脉夹层)、B组(n=20,非急性主动脉夹层)、C组(n=66,升主动脉瘤)、D组(n=59,降主动脉瘤),从本院同期体检者体检结论为正常的人群随机挑选130例作为E组。检测并比较Hcy水平和血液相关指标(血红蛋白、白细胞、D-二聚体、心肌酶、C-反应蛋白、肌酐、尿素)。结果A组的Hcy水平、高同型半胱氨酸血症(HHcy)发生率均显著高于其余4组,E组的Hcy水平、HHcy发生率显著低于其余4组,差异均有统计学意义(P<0.05)。B组年龄显著高于A组,差异有统计学意义(P<0.05)。患主动脉疾病的4组高血压病患病率明显高于E组,差异有统计学意义(P<0.05)。A组的D-二聚体、心肌酶及C-反应蛋白显著高于其余4组,E组的D-二聚体、心肌酶及C反应蛋白明显低于其余4组,差异有统计学意义(P<0.05)。多元Logistic回归分析显示,HHcy是主动脉疾病的独立危险因素(P<0.05)。结论与正常人群比较,主动脉疾病患者表现出更高的Hcy水平,急性主动脉夹层患者尤其显著。HHcy是主动脉疾病的危险因素。
Objective To investigate the relationship between homocysteine(Hcy)level and the risk of aortic disease.Methods A total of 220 patients with aortic disease admitted to the First Hospital of China Medical University from January 2018 to August 2023 were selected as the study subjects.According to the type of aortic disease,the patients were divided into group A(n=75,acute aortic dissection),Group B(n=20,non-acute aortic dissection),Group C(n=66,ascending aortic aneurysm),and Group D(n=59,descending aortic aneurysm).Patients who had normal physical examination results at the same time in our hospital were randomly selected as group E(n=130).Hcy levels and blood-related indicators(hemoglobin,white blood cells,D-dimer,myocardial enzyme,C-reactive protein,creatinine,urea)were measured and compared.Results The Hcy level and the high homocysteine(HHcy)in group A were significantly higher than those in the other 4 groups,and the Hcy level and HHcy incidence in group E were significantly lower than those in the other 4 groups,with statistical significance(P<0.05).The age of group B was significantly higher than that of group A,and the difference was statistically significant(P<0.05).The prevalence of hypertension in group 4 with aortic disease was significantly higher than that in group E,and the difference was statistically significant(P<0.05).The D-dimer,myocardial enzyme and C-reactive protein of group A were significantly higher than those of the other 4 groups,while the D-dimer,myocardial enzyme and C-reactive protein of group E were significantly lower than those of the other 4 groups,with statistical significance(P<0.05).Multiple Logistic regression analysis showed that HHcy was an independent risk factor for aortic disease.Conclusion Compared with the normal group,patients with aortic disease showed higher Hcy levels,especially in the acute aortic dissection group.HHcy is a risk factor for aortic disease.
作者
刘佳
李枭雄
黄姣
LIU Jia;LI Xiao-xiong;HUANG Jiao(Department of Cardiac Surgery,the First Hospital of China Medical University,Shenyang 110000,China)
出处
《创伤与急危重病医学》
2024年第2期79-83,共5页
Trauma and Critical Care Medicine
基金
国家自然科学基金面上项目(81471267)。
