摘要
目的分析龈沟液中骨桥蛋白(OPN)、C反应蛋白(CRP)及核因子⁃κB受体活化因子配体(RANKL)水平与种植体周围炎(PI)的关系。方法选取2021年6月至2023年3月成都京东方医院口腔科收治的PI患者87例为PI组,另选取同期种植体健康的实施牙种植修复患者80例作为对照组。对比两组OPN、CRP、RANKL水平以及牙周临床指标;分析OPN、CRP、RANKL水平与PI的相关性;统计患者预后情况,对比PI组不同预后患者的OPN、CRP、RANKL水平。结果PI组OPN、CRP、RANKL水平均比对照组高,差异有统计学意义(P<0.05);PI组改良牙龈指数、改良出血指数、探诊深度高于对照组,差异有统计学意义(P<0.05);OPN、CRP、RANKL与改良牙龈指数、改良出血指数、探诊深度呈正相关关系(P<0.05);87例患者中有58例患者预后良好,29例患者预后不良,预后不良组OPN、CRP、RANKL水平均比预后良好组高,差异有统计学意义(P<0.05)。结论PI患者龈沟液OPN、CRP及RANKL均异常高表达,且与改良牙龈指数、改良出血指数评分以及探诊深度具有相关性,可通过检测龈沟液OPN、CRP及RANKL水平评估PI患者预后情况,为临床治疗提供依据。
Objective To analyze the relationship between the levels of osteopontin(OPN),C⁃reactive protein(CRP)and receptor activator of nuclear factor⁃kB ligand(RANKL)in gingival crevicular fluid and peri⁃implantitis(PI).Methods 87 cases of PI patients admitted to the Dental Department of Boe Hospital,Chengdu from Jun 2021 to Mar 2023 were retrospectively analyzed as the PI group.Another 80 patients undergoing dental implant restoration with healthy implants were selected as control group.The levels of OPN,CRP,RANKL and periodontal clinical indicators were compared between the two groups,and the correlation between OPN,CRP,RANKL levels and PI was analyzed.The prognosis was counted,and the levels of OPN,CRP and RANKL in patients with different prognosis in PI group were compared.Results The levels of OPN,CRP,and RANKL were higher in the PI group than in the control group,and the difference was statistically significant(P<0.05).The improved gingival index,d bleeding index,and probing depth of the PI group were also higher than those of the control group(P<0.05).There was a positive correlation between OPN,CRP,and RANKL and the improved gingival index,bleeding index,and probing depth(P<0.05).It was found that 58 out of 87 patients had a good prognosis,and 29 had a poor prognosis.OPN,CRP,and RANKL levels were higher in the poor prognosis group than in the good prognosis group,and the difference was statistically significant(P<0.05).Conclusion The levels of OPN,CRP and RANKL in the gingival sulcus fluid of patients with PI were found to be abnormally high and correlated with the modified gingival index,modified bleeding index score and probing depth.Therefore,assessing the prognosis of patients with PI can be done by detecting these levels in the gingival sulcus fluid.This information can provide a basis for clinical treatment.
作者
李爱霞
王亚君
马骎
LI Aixia;WANG Yajun;MA Qin(Department of Stomatology,Chengdu BOE Hospital,Chengdu,Sichuan,China,610000;Department of Out-patient,Chengdu Chenghua Squirrel Oral Clinic,Chengdu,Sichuan,China,610000;Department of Stomatology,Shenmu Hospital Affiliated to Northwest University,Shenmu,Shanxi,China,719300)
出处
《分子诊断与治疗杂志》
2024年第8期1476-1479,共4页
Journal of Molecular Diagnostics and Therapy
基金
四川省科技计划项目(2023YJ0242)。
