摘要
目的探究妊娠期糖尿病(gestational diabetes mellitus,GDM)患者治疗中地特胰岛素与门冬胰岛素联合应用对妊娠结局的影响。方法回顾性选取2023年1月—2024年1月泉州市第一医院收治的100例GDM患者的临床资料,根据不同治疗措施分为常规组(n=50,单纯应用门冬胰岛素治疗)、观察组(n=50,门冬胰岛素与地特胰岛素联合应用)。比较两组血糖水平(糖化血红蛋白、空腹血糖、餐后2 h血糖)、不良妊娠结局(羊水过多、新生儿低血糖、胎膜早破、巨大儿)、临床疗效。结果分娩前,两组血糖水平均低于治疗前,且观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于常规组,差异有统计学意义(P均<0.05)。观察组不良妊娠结局发生率低于常规组,临床疗效高于常规组,差异有统计学意义(P均<0.05)。结论GDM患者治疗中选择门冬胰岛素与地特胰岛素联用方案,血糖调节效果更佳,不良妊娠结局发生风险更低,临床疗效显著。
Objective To explore the effect of combined application of insulin detemir and insulin aspart on preg-nancy outcome in patients with gestational diabetes mellitus(GDM).Methods The clinical data of 100 GDM patients admitted to Quanzhou First Hospital from January 2023 to January 2024 were retrospectively selected.According to different treatment measures,they were divided into the conventional group(n=50,treated with insulin aspart only)and the observation group(n=50,treated with insulin aspart combined with insulin detemir).The blood glucose levels(glycated hemoglobin A1c,fasting plasma glucose,2-hour postprandial plasma glucose),adverse pregnancy outcomes(polyhydramnios,neonatal hypoglycemia,premature rupture of membranes,macrosomia),and clinical efficacy were compared between the two groups.Results Before delivery,the blood glucose levels of the two groups were lower than those before treatment,and the fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c levels of the observation group were lower than those of the conventional group,and the differences were statistically significant(all P<0.05).The incidence of adverse pregnancy outcomes in the observation group was lower than that in the conventional group,and the clinical efficacy was higher than that in the conventional group,and the differ-ences were statistically significant(both P<0.05).Conclusion In the treatment of GDM patients,the combination of insulin aspart and insulin detemir is selected,the effect of blood glucose regulation is better,the risk of adverse pregnancy outcomes is lower,and the clinical efficacy is significant.
作者
陈婷婷
施美娘
张丽芬
CHEN Tingting;SHI Meiniang;ZHANG Lifen(Quanzhou First Hospital,Quanzhou 362000,Fujian,China)
出处
《糖尿病新世界》
2024年第12期78-81,共4页
Diabetes New World
关键词
妊娠期糖尿病
门冬胰岛素
地特胰岛素
妊娠结局
临床疗效
Gestational diabetes mellitus
Insulin aspart
Insulin detemir
Pregnancy outcome
Clinical efficacy
