摘要
目的探讨重组α干扰素-2b和异丙托溴铵雾化吸入在小儿毛细支气管炎治疗中的临床效果。方法选取2020年4月至2022年8月湖州市中心医院诊治的112例毛细支气管炎患儿,根据信封法将其分为对照组和观察组,每组各56例。对照组患儿给予异丙托溴铵雾化吸入,观察组患儿给予重组α干扰素-2b雾化吸入,两组患儿均连续治疗7d。比较两组患儿的肺功能、γ干扰素(interferon-γ,IFN-γ)、白细胞介素-10(interleukin-10,IL-10)、免疫功能及不良反应。结果干预7d后,观察组患儿的喘息、咳嗽、肺部湿啰音及痰鸣音消失时间均显著短于对照组(P<0.05);两组患儿的潮气量(tidal volume,TV)、潮气呼气峰流量(peak tidal expiratory flow,PTEF)及达峰时间比(ratio of time to peak tidal expiratory flow to total expiratory time,TPTEF/TE)、IFN-γ及IL-10均显著高于本组干预前(P<0.05),观察组患儿的TV、PTEF、TPTEF/TE、IFN-γ及IL-10水平均显著高于对照组(P<0.05);两组患儿的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均显著高于本组干预前,CD8^(+)显著低于本组干预前(P<0.05);观察组患儿的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均显著高于对照组,CD8^(+)显著低于对照组(P<0.05);两组患儿的不良反应发生率比较差异无统计学意义(χ^(2)=0.704,P=0.401)。结论毛细支气管炎患儿采用重组α干扰素-2b和异丙托溴铵雾化吸入均可获得良好的治疗效果,但前者有助于缩短症状消失时间,提高患儿免疫水平,值得临床推广应用。
Objective To investigate the clinical effect of recombinant interferon(IFN)-α-2b and ipratropium bromide atomized inhalation in pediatric bronchiolitis.Methods A total of 112 children with bronchiolitis diagnosed and treated in Huzhou Central Hospital from April 2020 to August 2022 were selected and divided into control group and observation group according to envelope method,with 56 cases in each group.The control group was treated with atomization inhalation of ipratropium bromide,and the observation group was treated with atomization inhalation of recombinant IFN-α-2b.Both groups completed 7 days of treatment,and the lung function,interferon-γ(IFN-γ),interleukin-10(IL-10),immune function and adverse reaction were compared between two groups.Results After 7 days of intervention,the disappearance time of wheezing,cough,lung moist rales and sputum sounds in observation group were significantly shorter than those in control group(P<0.05).The tidal volume(TV),peak tidal expiratory flow(PTEF),ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE),IFN-γand IL-10 in both groups were significantly higher than those before intervention(P<0.05).TV,PTEF,TPTEF/TE,IFN-γand IL-10 in observation group were higher than those in control group(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in both groups were significantly higher than before intervention,and the levels of CD8^(+)were significantly lower than before intervention(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in observation group were significantly higher than those in control group,and CD8^(+)was significantly lower than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(χ^(2)=0.704,P=0.401).Conclusion Both recombinant IFN-α-2b and ipratropium bromide atomized inhalation can achieve good therapeutic effect in children with bronchiolitis,but the former can help shorten the time of symptom disappearance and improve the immune level of children,and is worthy of clinical application.
作者
陈妙
沈小娟
潘文艳
CHEN Miao;SHEN Xiaojuan;PAN Wenyan(Infusion Room,Huzhou Normal University Affiliated Central Hospital,Huzhou 313000,Zhejiang,China;Department of Interventional Radiotherapy,Huzhou Normal University Affiliated Central Hospital,Huzhou 313000,Zhejiang,China)
出处
《中国现代医生》
2024年第25期85-88,共4页
China Modern Doctor
