摘要
目的:研究低渗性口服补液盐联合消旋卡多曲对小儿轮状病毒性肠炎的疗效。方法:选择2021年1月至2023年5月本院的89例轮状病毒性肠炎患儿,随机分为两组。对照组口服低渗性口服补液盐,观察组联合口服消旋卡多曲。比较两组的疗效,记录两组的止吐、大便次数、性状恢复和退热时间,且检测血清白介素(IL)-10及IL-17水平。结果:观察组的总有效率明显高于对照组(P<0.05);观察组的止吐、大便次数、性状恢复和退热时间明显短于对照组(P<0.05);治疗前,两组患儿的血清IL-10及IL-17水平无明显差异(P0.05),治疗后,两组患儿的血清IL-10水平均明显升高(P<0.05),IL-17水平均明显降低(P<0.05),且观察组患儿的血清IL-10及IL-17水平明显优于对照组(P<0.05);两组的恶心、发热、脱水和呕吐发生率无明显差异(P>0.05)。结论:低渗性口服补液盐联合消旋卡多曲能有效调节轮状病毒肠炎患儿的血清IL-10及IL-17水平,调节其免疫反应,明显提高疗效。
Objective:To study the effect of hypoosmotic oral rehydration salts combined with racecadotril on infantile rotavirus enteritis.Methods:Selected 89 cases of patients with infantile rotavirus enteritis from January 2021 to May 2023,randomly di-vided into two groups,The control group was given oral hypoosmotic oral rehydration salts,while oral racecadotril was given to the observation group.Compare the therapeutic effects of the two groups,record the recovery time of stool frequency,antie-metic time,recovery time of stool characteristics,and fever reduction time of the two groups,and detect serum levels of inter-leukin-10(IL-10)and IL-17.Results:Compare to the effective rate of the control group,that in the observation group was significantly higher(P<0.05).Compare to the recovery time of stool frequency,antiemetic time,recovery time of stool char-acter and antifebrile time in the control group,those in the observation group were significantly shorter(P<o.05).Before treatment,there was no significant difference in serum IL-10 and IL-17 levels between the two groups of children(P>0.05).After treatment,the serum IL-10 levels of both groups of children were increased(P<0.05),while IL-17 levels were signifi-cantly reduced(P<0.05).Moreover,Compare to the serum IL-10 and IL-17 levels of the control group,those of the obser-vation group were significantly better(P<o.05).There was no significant difference in the incidence of nausea,fever,dehy-dration and vomiting between the two groups(P>0.05).Conclusion:Hypotonic oral rehydration salts combined with racec-adotril can effectively regulate the serum levels of IL-10 and IL-17 in children with rotavirus enteritis,regulate their immune re-sponse and significantly improve the curative effect.
作者
姜立溪
于亚杰
Jiang Lixi;Yu Yajie(Department of Paediatrics,Wengniut Banner People's Hospital,Chifeng Inner Mongolia,024000,China)
出处
《中外女性健康研究》
2024年第9期5-7,30,共4页
Women＇s Health Research
